Hemolytic disease of the fetus and newborn caused by anti-sD antibody in a GP.Mur/Mur Thai mother and review of the prevalence of sD in Thai blood donors

Genghis H Lopez; Morakot Emthip; Ploymanee Suwanwootichai; Glenda M Millard; Brett Wilson; Sunisa Onpuns; Kanchana Laemsri; Pimol Chiewsilp; Robert Lewis Powell Flower; Catherine A Hyland; Yew-Wah Liew

doi:10.1111/trf.17086

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Hemolytic disease of the fetus and newborn caused by anti-sD antibody in a GP.Mur/Mur Thai mother and review of the prevalence of sD in Thai blood donors

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Hemolytic disease of the fetus and newborn caused by anti-sD antibody in a GP.Mur/Mur Thai mother and review of the prevalence of sD in Thai blood donors

Genghis H Lopez, Morakot Emthip, Ploymanee Suwanwootichai, Glenda M Millard, Brett Wilson, Sunisa Onpuns, Kanchana Laemsri, Pimol Chiewsilp, Robert Lewis Powell Flower, Catherine A Hyland, …

Transfusion, Vol.62(10), pp.2137-2142

2022

DOI: https://doi.org/10.1111/trf.17086

PMID: 36062546

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

MNS blood group system

anti-sD

haemolytic disease of the fetus and newborn

prevalence of sD in Thai blood donors

sD antigen

UniSC Diversity Area - Life Stages

Background: Low-prevalence antigen sD (MNS23) is encoded by GYPB c.173C > G. Hemolytic disease of the fetus and newborn (HDFN) due to anti-sD is rare. A mother delivered a newborn whose red blood cells (RBCs) were DAT-positive and was later diagnosed with HDFN. Serum from the mother was incompatible with the father's RBCs and was used to screen 184 Thai blood donors. This study aimed to investigate the cause of HDFN in a Thai family and determine the prevalence of sD in Thai blood donors. Materials and methods: Three family members and four blood donors were investigated in the study. Massively Parallel Sequencing (MPS) was used for genotyping. Standard hemagglutination techniques were used in titration studies, phenotyping, and enzyme/chemical studies. Anti-s, anti-Mia , anti-JENU, and anti-sD reagents were used in serological investigations. Results: The mother was GYP*Mur/Mur. The father and the four donors were GYPB*s/sD predicting S - s + sD +. The baby was GYP*Mur/sD and his RBCs were Mia +, s + w with anti-s (P3BER) and JENU+w . RBCs from two GYPB*sD -positive blood donors reacted with anti-sD (Dreyer). Proteolytic enzyme α-chymotrypsin-treated sD + cells did not react with anti-sD (Wat) produced by the GP.Mur/Mur mother but reacted with the original anti-sD (Dreyer). Discussion: This is the first report of HDFN due to anti-sD in the Asian population. The genotype frequency for GYPB*sD in a selected Thai blood donor population is 2.2% (4/184). Anti-sD should be considered in mothers with Southeast Asian or East Asian background when antibody identification is unresolved in pregnancies affected by HDFN.

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Title: Hemolytic disease of the fetus and newborn caused by anti-sD antibody in a GP.Mur/Mur Thai mother and review of the prevalence of sD in Thai blood donors
Authors: Genghis H Lopez (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Morakot Emthip (Author) - Thai Red Cross Society
Ploymanee Suwanwootichai (Author) - Thai Red Cross Society
Glenda M Millard (Author) - Australian Red Cross Blood Service
Brett Wilson (Author) - Australian Red Cross Blood Service
Sunisa Onpuns (Author) - Thai Red Cross Society
Kanchana Laemsri (Author) - Thai Red Cross Society
Pimol Chiewsilp (Author) - Thai Red Cross Society
Robert Lewis Powell Flower (Author) - Australian Red Cross Blood Service
Catherine A Hyland (Author) - Australian Red Cross Blood Service
Yew-Wah Liew (Author) - Australian Red Cross Blood Service
Publication details: Transfusion, Vol.62(10), pp.2137-2142
Publisher: Wiley-Blackwell Publishing, Inc.
Date published: 2022
DOI: 10.1111/trf.17086
ISSN: 1537-2995; 0041-1132
PMID: 36062546
Copyright note: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2022 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.
Grant note: Australian governments fund Australian Red Cross Lifeblood
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99673698002621
Output Type: Journal article

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Web Of Science research areas: Hematology

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