Journal article
Hemolytic disease of the fetus and newborn caused by anti-sD antibody in a GP.Mur/Mur Thai mother and review of the prevalence of sD in Thai blood donors
Transfusion, Vol.62(10), pp.2137-2142
2022
PMCID: PMC9826107
PMID: 36062546
Abstract
Background: Low-prevalence antigen sD (MNS23) is encoded by GYPB c.173C > G. Hemolytic disease of the fetus and newborn (HDFN) due to anti-sD is rare. A mother delivered a newborn whose red blood cells (RBCs) were DAT-positive and was later diagnosed with HDFN. Serum from the mother was incompatible with the father's RBCs and was used to screen 184 Thai blood donors. This study aimed to investigate the cause of HDFN in a Thai family and determine the prevalence of sD in Thai blood donors. Materials and methods: Three family members and four blood donors were investigated in the study. Massively Parallel Sequencing (MPS) was used for genotyping. Standard hemagglutination techniques were used in titration studies, phenotyping, and enzyme/chemical studies. Anti-s, anti-Mia , anti-JENU, and anti-sD reagents were used in serological investigations. Results: The mother was GYP*Mur/Mur. The father and the four donors were GYPB*s/sD predicting S - s + sD +. The baby was GYP*Mur/sD and his RBCs were Mia +, s + w with anti-s (P3BER) and JENU+w . RBCs from two GYPB*sD -positive blood donors reacted with anti-sD (Dreyer). Proteolytic enzyme α-chymotrypsin-treated sD + cells did not react with anti-sD (Wat) produced by the GP.Mur/Mur mother but reacted with the original anti-sD (Dreyer). Discussion: This is the first report of HDFN due to anti-sD in the Asian population. The genotype frequency for GYPB*sD in a selected Thai blood donor population is 2.2% (4/184). Anti-sD should be considered in mothers with Southeast Asian or East Asian background when antibody identification is unresolved in pregnancies affected by HDFN.
Details
- Title
- Hemolytic disease of the fetus and newborn caused by anti-sD antibody in a GP.Mur/Mur Thai mother and review of the prevalence of sD in Thai blood donors
- Authors
- Genghis H Lopez (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyMorakot Emthip (Author) - Thai Red Cross SocietyPloymanee Suwanwootichai (Author) - Thai Red Cross SocietyGlenda M Millard (Author) - Australian Red Cross Blood ServiceBrett Wilson (Author) - Australian Red Cross Blood ServiceSunisa Onpuns (Author) - Thai Red Cross SocietyKanchana Laemsri (Author) - Thai Red Cross SocietyPimol Chiewsilp (Author) - Thai Red Cross SocietyRobert Lewis Powell Flower (Author) - Australian Red Cross Blood ServiceCatherine A Hyland (Author) - Australian Red Cross Blood ServiceYew-Wah Liew (Author) - Australian Red Cross Blood Service
- Publication details
- Transfusion, Vol.62(10), pp.2137-2142
- Publisher
- Wiley-Blackwell Publishing, Inc.
- Date published
- 2022
- DOI
- 10.1111/trf.17086
- ISSN
- 1537-2995
- PMID
- 36062546; PMC9826107
- Copyright note
- This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2022 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.
- Grant note
- Australian governments fund Australian Red Cross Lifeblood
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99673698002621
- Output Type
- Journal article
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