Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism

Jason P Connor; Ross Young; Bruce R Lawford; John B Saunders; Terry L Ritchie; Ernest P Noble

doi:10.1016/j.addbeh.2006.04.006

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Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism

Journal article

Open access

Peer reviewed

Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism

Jason P Connor, Ross Young, Bruce R Lawford, John B Saunders, Terry L Ritchie and Ernest P Noble

Addictive Behaviors, Vol.32(2), pp.310-319

2007

DOI: https://doi.org/10.1016/j.addbeh.2006.04.006

PMID: 16766132

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Abstract

Comorbidity

DRD2 gene

Alcohol and nicotine dependence

Cigarette smoking in those who are alcohol dependent is associated with higher morbidity and mortality. The A1 allele of the D2 dopamine receptor (DRD2) gene has been independently associated with alcohol and nicotine dependence. Whether this polymorphism is associated with nicotine dependence in those who are also alcohol dependent has not been investigated. Subjects were 84 (61 males; 23 females) Caucasian DSM IV diagnosed nicotine- and alcohol-dependent subjects sampled from consecutive admissions to a hospital alcohol detoxification ward. Data were obtained through standardised measures of nicotine and alcohol consumption and dependence severity. A1+ allelic (A1/A1 or A1/A2 genotype) compared to A1− allelic (A2/A2 genotype only) patients were characterised by higher levels of alcohol and cigarette consumption. A1+ allelic patients reported greater alcohol dependence severity, but not nicotine dependence severity. When the combined nicotine and alcohol dose was examined, A1+ allelic patients consumed significantly more of these drugs than their A1− allelic counterparts.

Details

Title: Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism
Authors: Jason P Connor (Author) - The University of Queensland
Ross Young (Author) - Queensland University of Technology
Bruce R Lawford (Author) - Royal Brisbane and Women's Hospital
John B Saunders (Author) - The University of Queensland
Terry L Ritchie (Author) - University of California Los Angeles
Ernest P Noble (Author) - University of California Los Angeles
Publication details: Addictive Behaviors, Vol.32(2), pp.310-319
Publisher: Elsevier Ltd
Date published: 2007
DOI: 10.1016/j.addbeh.2006.04.006
ISSN: 1873-6327; 0306-4603
PMID: 16766132
Copyright note: Copyright © 2007. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Organisation Unit: University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
Language: English
Record Identifier: 99550995802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychology, Clinical; Substance Abuse

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