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Journal article
Healthcare-associated infections and antimicrobial use at a major referral hospital in Papua New Guinea: a point prevalence survey
The Lancet Regional Health. Western Pacific, Vol.48, pp.1-9
2024
Abstract
Background
Healthcare-associated infections (HAI) and antimicrobial use (AMU) are drivers for antimicrobial resistance, and robust data are required to inform interventions and track changes. We aimed to estimate the prevalence of HAI and AMU at Port Moresby General Hospital (PMGH), the largest hospital in Papua New Guinea.
Methods
We did a point prevalence survey (PPS) on HAI and AMU at PMGH in May 2023 using the European Centre for Disease Prevention and Control (ECDC) PPS protocol. We included all critical care patients and randomly sampled half of the patients in other acute-care wards. We calculated weighted HAI and AMU prevalence estimates to account for this sampling strategy. Weighted HAI estimates were also calculated for an expanded definition that included physician diagnosis.
Findings
Of 361 patients surveyed in 18 wards, the ECDC protocol identified 28 HAIs in 26 patients, resulting in a weighted HAI prevalence of 6.7% (95% CI: 4.6, 9.8). Surgical site infections (9/28, 32%) were the most common HAI. When adding physician diagnosis to the ECDC definitions, more skin and soft tissue, respiratory, and bloodstream HAIs were detected, and the weighted HAI prevalence was 12.4% (95% CI: 9.4, 16.3). The prevalence of AMU was 66.5% (95%CI: 61.3, 71.2), and 73.2% (263/359) of antibiotics were from the World Health Organization Access group.
Interpretation
This is the first reported hospital PPS of HAI and AMU in Papua New Guinea. These results can be used to prioritise interventions, and as a baseline against which future point prevalence surveys can be compared.
Funding
Australian Government Department of Foreign Affairs and Trade and Therapeutic Guidelines Limited Australia.
Details
- Title
- Healthcare-associated infections and antimicrobial use at a major referral hospital in Papua New Guinea: a point prevalence survey
- Authors
- Stephanie J Curtis (Corresponding Author) - Monash UniversityRoland Barnabas - Port Moresby General HospitalKelly A Cairns - Monash UniversityDonna Cameron - The University of MelbourneBenjamin Coghlan - Burnet InstituteRobert Jones - Port Moresby General HospitalJacklyn Joseph - Port Moresby General HospitalAlu Kali - Port Moresby General HospitalDimitri Kep - Port Moresby General HospitalGemma Klintworth - Monash UniversityStephanie Levy - Burnet InstituteMatt Mason - University of the Sunshine Coast, Queensland, School of Health - NursingMajella Norrie - Port Moresby General HospitalTrisha Peel - Monash UniversityGilam Tamolsaian - Burnet InstituteJosephine Telenge - Port Moresby General HospitalNellie Tumu - Port Moresby General HospitalAndrew J Stewardson - Monash UniversityGabriella Ak - Port Moresby General HospitalCOMBAT-AMR Group (Group Member)
- Publication details
- The Lancet Regional Health. Western Pacific, Vol.48, pp.1-9
- Publisher
- The Lancet Publishing Group
- Date published
- 2024
- DOI
- 10.1016/j.lanwpc.2024.101120
- ISSN
- 2666-6065
- Copyright note
- © 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Data Availability
- The data that support the findings of this study are available from the corresponding author, SJC, upon reasonable request, subject to approval by the relevant institutional review boards.
- Organisation Unit
- Australian Centre for Pacific Islands Research; School of Health - Nursing
- Language
- English
- Record Identifier
- 991037098902621
- Output Type
- Journal article
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