Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele

Ross Young; Bruce R Lawford; E. P Noble; Burnett Kann; A Wilkie; Terry L Ritchie; L Arnold; S Shadforth

doi:10.1093/alcalc/37.5.451

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Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele

Journal article

Peer reviewed

Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele

Ross Young, Bruce R Lawford, E. P Noble, Burnett Kann, A Wilkie, Terry L Ritchie, L Arnold and S Shadforth

Alcohol and Alcoholism, Vol.37(5), pp.451-456

2002

DOI: https://doi.org/10.1093/alcalc/37.5.451

PMID: 12217937

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Abstract

Aims: The frequency of the Taq I A alleles (A1 and A2) of the D2 dopamine receptor (DRD2) gene was examined in Caucasian post-traumatic stress disorder (PTSD) patients and controls. Results: In 91 PTSD patients, the frequency of the A1 allele was higher (P = 6.12 × 10−3) than in the 51 controls. In the 38 PTSD harmful drinkers (≥60 g alcohol/day), A1 allelic frequency was higher (P = 3.91 × 10−2) than in the 53 non-harmful drinkers (<60 g alcohol/day), the former being also higher (P = 3.76 × 10−4) than in controls. However, there was no difference between non-harmful drinkers and controls. Based on DRD2 allelic association, the 35 PTSD patients with the A1+ (A1A1, A1A2) allele consumed more than twice the daily amount of alcohol than the 56 patients with the A1− (A2A2) allele (P = 1.94 × 10−3). When the hourly rate of alcohol consumed was compared, A1+ allelic patients consumed twice the rate of the A1− allelic patients (P < 10−7). Conclusion: The DRD2 A1 allele was associated with PTSD. However, this association was found only in the harmful drinkers. PTSD patients with the A1+ allele consumed more alcohol than patients with the A1− allele. The importance of determining alcohol consumption in DRD2 association studies with PTSD is suggested.

Details

Title: Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele
Authors: Ross Young (Author) - University of Queensland
Bruce R Lawford (Author) - University of Queensland
E. P Noble (Author) - University of California, Los Angeles
Burnett Kann (Author) - Nambour Hospital, Nambour, Queensland, Australia
A Wilkie (Author) - Greenslopes Private Hospital
Terry L Ritchie (Author) - University of California, Los Angeles
L Arnold (Author) - Royal Brisbane Hospital
S Shadforth (Author) - Greenslopes Private Hospital
Publication details: Alcohol and Alcoholism, Vol.37(5), pp.451-456
Publisher: Oxford University Press
DOI: 10.1093/alcalc/37.5.451
ISSN: 1464-3502
PMID: 12217937
Organisation Unit: Office of the Deputy Vice-Chancellor (Research and Innovation); University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99550996002621
Output Type: Journal article

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Web Of Science research areas: Substance Abuse

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