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Haematological, Biochemical and Hormonal Biomarkers of Heat Intolerance in Military Personnel1,020.17 kB
Published VersionCC BY V4.0, Open Access
Journal article
Haematological, Biochemical and Hormonal Biomarkers of Heat Intolerance in Military Personnel
Biology, Vol.10(10), pp.1-15
2021
PMCID: PMC8533107
PMID: 34681165
Abstract
Heat intolerance is the inability to withstand heat stress and this may occur due to exertional heat stroke (EHS). However, it is unknown if heat intolerance is associated with immune and hormonal disturbances. This study investigates haematological, biochemical and hormonal biomarkers related to heat intolerance and EHS in military and civilian volunteers. A quasi-experimental pre-and post-test design was used, with participants drawn from the Australian Defence Force (ADF) and the general populace. Blood samples were collected and analysed for biomarkers. Inferential statistics compared the biomarkers between the groups. Changes in alanine amino transaminase (p = 0.034), creatine kinase (0.044), cortisol (p = 0.041) and creatinine (p < 0.001) differed between the heat-intolerant and heat-tolerant groups. Participants with a history of EHS showed significant changes in creatinine (p = 0.022) and urea (p = 0.0031) compared to those without EHS history. Predictors of heat intolerance were increasing post-HTT creatinine and cortisol (OR = 1.177, p = 0.011 and OR = 1.015, p = 0.003 respectively). Conclusively, EHS history is associated with changes in creatinine and urea concentrations, while the predictors of heat intolerance are creatinine and cortisol. However, further exploration of other biomarkers, such as genetic polymorphism, is needed.
Details
- Title
- Haematological, Biochemical and Hormonal Biomarkers of Heat Intolerance in Military Personnel
- Authors
- Faith O. Alele (Corresponding Author) - James Cook UniversityBunmi S. Malau-Aduli (Author) - James Cook UniversityAduli E. O. Malau-Aduli (Author) - James Cook UniversityMelissa J. Crowe (Author) - Australian Institute of Tropical Health and Medicine
- Publication details
- Biology, Vol.10(10), pp.1-15
- Publisher
- MDPI AG
- Date published
- 2021
- DOI
- 10.3390/biology10101068
- ISSN
- 2079-7737
- PMID
- 34681165; PMC8533107
- Copyright note
- Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Grant note
- Australian International Postgraduate Research Training Scholarship
- Organisation Unit
- School of Health - Public Health
- Language
- English
- Record Identifier
- 99967595902621
- Output Type
- Journal article
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