HIV, Immune Dysfunction, and the Natural History of Anal High-Risk Human Papillomavirus Infection in Gay and Bisexual Men

I Mary Poynten; Fengyi Jin; Suzanne M Garland; Richard J Hillman; Monica Molano; Jennifer M Roberts; David J Templeton; Samuel Phillips; Carmella Law; Christopher K Fairley; Annabelle Farnsworth; Andrew E Grulich

doi:10.1093/infdis/jiaa723

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HIV, Immune Dysfunction, and the Natural History of Anal High-Risk Human Papillomavirus Infection in Gay and Bisexual Men

Journal article

Peer reviewed

HIV, Immune Dysfunction, and the Natural History of Anal High-Risk Human Papillomavirus Infection in Gay and Bisexual Men

I Mary Poynten, Fengyi Jin, Suzanne M Garland, Richard J Hillman, Monica Molano, Jennifer M Roberts, David J Templeton, Samuel Phillips, Carmella Law, Christopher K Fairley, …

Journal of Infectious Diseases, Vol.224(2), pp.246-257

2021

DOI: https://doi.org/10.1093/infdis/jiaa723

PMID: 33220687

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Abstract

anal cancer

gay and bisexual men

HIV

HPV

screening

anal

Background: Incidence of anal cancer is highest in gay and bisexual men (GBM). Better understanding of the natural history of anal high-risk human papillomavirus (hrHPV) infection is needed for anal cancer prevention. Methods: The Study of the Prevention of Anal Cancer was a 3-year study of Australian GBM, aged 35 years or older. We examined incidence, clearance, and risk factors for 13 hrHPV types at baseline and 3 annual visits. Results: In 525 men with ≥ 2 visits, 348 (66.3%) acquired ≥ 1 incident hrHPV infection. HPV16 incidence rates were similar, but non-16 hrHPV incidence was higher in HIV-positive (51.8/100 person years [PY]) than HIV-negative men (36.5/100 PY, P < .001). Annual clearance rates of HPV16 (13.21/100 PY, 95% confidence interval, 10.53-16.56) were lower than for other hrHPV types. hrHPV clearance rates were not associated with HIV overall but were significantly lower in those with a lower nadir CD4 (<200 cells/µL) for HPV16 (P = .015) and other hrHPV types (P = .007). Conclusions: Higher incidence of non-16 hrHPV types, coupled with lower clearance of non-16 hrHPV types in those with past impaired immune function, is consistent with the greater role of non-16 hrHPV in anal cancer in HIV-positive people.

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Title: HIV, Immune Dysfunction, and the Natural History of Anal High-Risk Human Papillomavirus Infection in Gay and Bisexual Men
Authors: I Mary Poynten (Corresponding Author) - UNSW Sydney
Fengyi Jin (Author) - UNSW Sydney
Suzanne M Garland (Author) - Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia
Richard J Hillman (Author) - St Vincent's Health
Monica Molano (Author) - Royal Women's Hospital
Jennifer M Roberts (Author) - Douglass Hanly Moir Pathology, New South Wales, Sydney, Australia
David J Templeton (Author) - University of Sydney
Samuel Phillips (Author) - Royal Women's Hospital
Carmella Law (Author) - St Vincent's Hospital, Darlinghurst, New South Wales, Australia
Christopher K Fairley (Author) - University of Melbourne
Annabelle Farnsworth (Author) - Douglass Hanly Moir Pathology
Andrew E Grulich (Author) - UNSW Sydney
Publication details: Journal of Infectious Diseases, Vol.224(2), pp.246-257
Publisher: Oxford University Press
DOI: 10.1093/infdis/jiaa723
ISSN: 1537-6613
PMID: 33220687
Organisation Unit: Centre for Bioinnovation; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99640379002621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology

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