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Guidelines for RNA-seq projects: applications and opportunities in non-model decapod crustacean species
Journal article   Open access   Peer reviewed

Guidelines for RNA-seq projects: applications and opportunities in non-model decapod crustacean species

Tuan Viet Nguyen, Hyungtaek Jung, Guiomar Rotllant, David Hurwood, Peter Mather and Tomer Ventura
Hydrobiologia, Vol.825(1), pp.5-27
2018
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https://doi.org/10.1007/s10750-018-3682-0View
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Abstract

RNA-sequencing next-generation sequencing differential gene expression shrimp prawn crab lobster crayfish in silico
Next-generation sequencing (NGS) has dramatically changed the way biological research is being conducted in the post-genomic era, and they have only been utilized widely over the recent decade for studies of non-model decapod crustacean species, predominantly by sequencing the transcriptome of various tissues across different life stages. Next-generation sequencing can now provide a rapid, cost-effective solution for discovery of genetic markers crucial in many applications that would previously have otherwise taken years to develop. Sequencing of the entire transcriptome (referred to as RNA sequencing; RNA-seq) is one of the most popular NGS tools. RNA-seq studies of non-model species in crustacean taxa, however, have faced some problems, including a lack of "good" experimental study design, a relative paucity of gene annotations, combined with limited knowledge of genomic technologies and analyses. The aim of the current review is to assist crustacean biologists to develop a better appreciation for the applications and scope of RNA-seq analysis, understand the basic requirements for optimal RNA-seq studies and provide an overview of each step, from RNA-seq experimental design to bioinformatics approaches to data analysis. Insights that have resulted from RNA-seq studies across a wide range of non-model decapod species are also summarized.

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