Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species

Namki Cho; Tanya T Ransom; Janet Sigmund; Trong D Tran; Robert H Cichewicz; Michael Goetz; John A Beutler

doi:10.1021/acs.jnatprod.7b00170

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Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species

Journal article

Peer reviewed

Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species

Namki Cho, Tanya T Ransom, Janet Sigmund, Trong D Tran, Robert H Cichewicz, Michael Goetz and John A Beutler

Journal of Natural Products, Vol.80(7), pp.2037-2044

2017

DOI: https://doi.org/10.1021/acs.jnatprod.7b00170

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Abstract

Biological Sciences

Medical and Health Sciences

Chemical Sciences

Bioassay-guided fractionation of a colon cancer growth inhibitory extract of the fungus Paraconiothyrium sp. led to the isolation of eight new versiol derivatives (1, 3-8, 10) along with two known compounds. The structures were elucidated by interpretation of combined MS and 2D NMR spectroscopic data. Compounds 8, 9, and 10 showed cell growth inhibition against COLO205 and KM12 cells, and both 8 and 9 displayed selectivity in their inhibition of melanoma cell lines in the NCI 60 one-dose test. In addition, compound 8 and the crude Paraconiothyrium sp. extract showed potent dose-dependent inhibitory effects in the five-dose NCI 60 cell line assay.

Details

Title: Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species
Authors: Namki Cho (Author) - National Cancer Institute, United States
Tanya T Ransom (Author) - National Cancer Institute, United States
Janet Sigmund (Author) - Natural Products Discovery Institute, United States
Trong D Tran (Author) - National Cancer Institute, United States
Robert H Cichewicz (Author) - University of Oklahoma, United States
Michael Goetz (Author) - Natural Products Discovery Institute, United States
John A Beutler (Author) - National Cancer Institute, United States
Publication details: Journal of Natural Products, Vol.80(7), pp.2037-2044
Publisher: American Chemical Society
DOI: 10.1021/acs.jnatprod.7b00170
ISSN: 0163-3864
Organisation Unit: Centre for Bioinnovation; School of Science and Engineering - Legacy; School of Science, Technology and Engineering; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99451130402621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Chemistry, Medicinal; Pharmacology & Pharmacy; Plant Sciences

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