Greater male than female variability in regional brain structure across the lifespan

Lara M Wierenga; Gaelle E Doucet; Danai Dima; Ingrid Agartz; Moji Aghajani; Theophilus N Akudjedu; Anton Albajes-Eizagirre; Dag Alnaes; Kathryn I Alpert; Ole A Andreassen; Alan Anticevic; Philip Asherson; Tobias Banaschewski; Nuria Bargallo; Sarah Baumeister; Ramona Baur-Streubel; Alessandro Bertolino; Aurora Bonvino; Dorret I Boomsma; Stefan Borgwardt; Josiane Bourque; Anouk den Braber; Daniel Brandeis; Alan Breier; Henry Brodaty; Rachel M Brouwer; Jan K Buitelaar; Geraldo Filho Busatto; Vince Calhoun; Erick J Canales-Rodriguez; Dara M Cannon; Xavier Caseras; Francisco X Castellanos; Tiffany M Chaim-Avancini; Christopher R K Ching; Vincent P Clark; Patricia J Conrod; Annette Conzelmann; Fabrice Crivello; Erin W Dickie; Christopher G Davey; Stefan Ehrlich; Dennis van 't Ent; Simon E Fisher; Jean-Paul Fouche; Barbara Franke; Paola Fuentes-Claramonte; Eco J C de Geus; Annabella Di Giorgio; David C Glahn; Ian H Gotlib; Hans J Grabe; Oliver Gruber; Patricia Gruner; Raquel E Gur; Ruben C Gur; Tiril P Gurholt; Lieuwe de Haan; Beathe Haatveit; Catharina A Hartman; Ben J Harrison; Sean N Hatton; Dirk J Heslenfeld; Odile A van den Heuvel; Ian B Hickie; Pieter J Hoekstra; Sarah Hohmann; Avram J Holmes; Martine Hoogman; Norbert Hosten; Fleur M Howells; Hilleke E Hulshoff Pol; Chaim Huyser; Neda Jahanshad; Anthony C James; Jiyang Jiang; Erik G Jonsson; John A Joska; Andrew J Kalnin; Marieke Klein; Laura Koenders; Knut K Kolskar; Bernd Kramer; Jonna Kuntsi; Jim Lagopoulos; Luisa Lazaro; Irina S Lebedeva; Phil H Lee; Christine Lochner; Marise W J Machielsen; Sophie Maingault; Nicholas G Martin; Ignacio Martinez-Zalacain; David Mataix-Cols; Bernard Mazoyer; Brenna C McDonald; Colm McDonald; Andrew M McIntosh; Katie L McMahon; Genevieve McPhilemy; Dennis van der Meer; Jose M Menchon; Jilly Naaijen; Lars Nyberg; Jaap Oosterlaan; Yannis Paloyelis; Paul Pauli; Giulio Pergola; Edith Pomarol-Clotet; Maria J Portella; Joaquim Radua; Andreas Reif; Genevieve Richard; Joshua L Roffman; Pedro G P Rosa; Matthew D Sacchet; Perminder S Sachdev; Raymond Salvador; Salvador Sarro; Theodore D Satterthwaite; Andrew J Saykin; Mauricio H Serpa; Kang Sim; Andrew Simmons; Jordan W Smoller; Iris E Sommer; Carles Soriano-Mas; Dan J Stein; Lachlan T Strike; Philip R Szeszko; Henk S Temmingh; Sophia I Thomopoulos; Julian N Trollor; Alexander S Tomyshev; Anne Uhlmann; Ilya M Veer; Dick J Veltman; Aristotle Voineskos; Henry Völzke; Henrik Walter; Lei Wang; Wang Yang; Bernd Weber; Wei Wen; John D West; Lars T Westlye; Heather C Whalley; Steven C R Williams; Katharina Wittfeld; Daniel H Wolf; Margaret J Wright; Yuliya N Yoncheva; Marcus V Zanetti; Georg C Ziegler; Greig I de Zubicaray; Paul M Thompson; Eveline A Crone; Sophia Frangou; Christian K Tamnes

doi:10.1002/hbm.25204

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Greater male than female variability in regional brain structure across the lifespan

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Greater male than female variability in regional brain structure across the lifespan

Lara M Wierenga, Gaelle E Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn I Alpert, Ole A Andreassen, …

Human Brain Mapping, Vol.43(1), pp.470-499

2022

DOI: https://doi.org/10.1002/hbm.25204

PMCID: PMC8675415

PMID: 33044802

Appears in Thompson Institute Research Collection

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Abstract

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Thompson Institute Special Collection

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1‐90 years old (47% females). We observed significant patterns of greater male than female between‐subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene‐environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex‐specific vulnerability to disorders.

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Title: Greater male than female variability in regional brain structure across the lifespan
Authors: Lara M Wierenga (Corresponding Author) - Leiden University
Gaelle E Doucet (Author) - Icahn School of Medicine at Mount Sinai
Danai Dima (Author) - University of London
Ingrid Agartz (Author) - University of Oslo
Moji Aghajani (Author) - Amsterdam UMC - Vrije Universiteit Amsterdam
Theophilus N Akudjedu (Author) - Ollscoil na Gaillimhe – University of Galway
Anton Albajes-Eizagirre (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Dag Alnaes (Author) - University of Oslo
Kathryn I Alpert (Author) - Northwestern University
Ole A Andreassen (Author) - University of Oslo
Alan Anticevic (Author) - Yale University
Philip Asherson (Author) - King's College London
Tobias Banaschewski (Author) - Heidelberg University
Nuria Bargallo (Author) - Hospital Clínic de Barcelona
Sarah Baumeister (Author) - Heidelberg University
Ramona Baur-Streubel (Author) - University of Würzburg
Alessandro Bertolino (Author) - University of Bari Aldo Moro
Aurora Bonvino (Author) - University of Bari Aldo Moro
Dorret I Boomsma (Author) - VU University Amsterdam
Stefan Borgwardt (Author) - University of Basel
Josiane Bourque (Author) - University of Pennsylvania
Anouk den Braber (Author) - VU University Amsterdam
Daniel Brandeis (Author) - Heidelberg University
Alan Breier (Author) - Indiana University School of Medicine - Lafayette
Henry Brodaty (Author) - University of Zurich
Rachel M Brouwer (Author) - Utrecht University
Jan K Buitelaar (Author) - Radboud University Medical Center
Geraldo Filho Busatto (Author) - University of Sao Paulo
Vince Calhoun (Author) - Georgia Institute of Technology
Erick J Canales-Rodriguez (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Dara M Cannon (Author) - Ollscoil na Gaillimhe – University of Galway
Xavier Caseras (Author) - Cardiff University
Francisco X Castellanos (Author) - New York University School of Medicine
Tiffany M Chaim-Avancini (Author) - University of Sao Paulo
Christopher R K Ching (Author) - University of Southern California
Vincent P Clark (Author) - University of New Mexico
Patricia J Conrod (Author) - Centre Hospitalier Universitaire Sainte-Justine
Annette Conzelmann (Author) - University of Tübingen
Fabrice Crivello (Author) - Institut des Maladies Neurodégénératives
Erin W Dickie (Author) - University of Toronto
Christopher G Davey (Author) - The University of Melbourne
Stefan Ehrlich (Author) - University Hospital Carl Gustav Carus
Dennis van 't Ent (Author) - VU University Amsterdam
Simon E Fisher (Author) - Max Planck Institute for Psycholinguistics
Jean-Paul Fouche (Author) - University of Cape Town
Barbara Franke (Author) - Radboud University Nijmegen
Paola Fuentes-Claramonte (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Eco J C de Geus (Author) - VU University Amsterdam
Annabella Di Giorgio (Author) - Casa Sollievo della Sofferenza
David C Glahn (Author) - Boston Children's Hospital
Ian H Gotlib (Author) - Stanford University
Hans J Grabe (Author) - Universität Greifswald
Oliver Gruber (Author) - University Hospital Heidelberg
Patricia Gruner (Author) - Yale University
Raquel E Gur (Author) - University of Pennsylvania
Ruben C Gur (Author) - University of Pennsylvania
Tiril P Gurholt (Author) - University of Oslo
Lieuwe de Haan (Author) - Amsterdam UMC Location Vrije Universiteit Amsterdam
Beathe Haatveit (Author) - University of Oslo
Catharina A Hartman (Author) - University of Groningen
Ben J Harrison (Author) - The University of Melbourne
Sean N Hatton (Author) - University of California San Diego
Dirk J Heslenfeld (Author) - Amsterdam UMC - Vrije Universiteit Amsterdam
Odile A van den Heuvel (Author) - Amsterdam UMC - Vrije Universiteit Amsterdam
Ian B Hickie (Author) - The University of Sydney
Pieter J Hoekstra (Author) - University of Groningen
Sarah Hohmann (Author) - Heidelberg University
Avram J Holmes (Author) - Yale University
Martine Hoogman (Author) - Radboud University Nijmegen
Norbert Hosten (Author) - Universität Greifswald
Fleur M Howells (Author) - University of Cape Town
Hilleke E Hulshoff Pol (Author) - Utrecht University
Chaim Huyser (Author) - De Bascule
Neda Jahanshad (Author) - University of Southern California
Anthony C James (Author) - Warneford Hospital
Jiyang Jiang (Author) - UNSW Australia
Erik G Jonsson (Author) - University of Oslo
John A Joska (Author) - University of Cape Town
Andrew J Kalnin (Author) - The Ohio State University
Marieke Klein (Author) - Utrecht University
Laura Koenders (Author) - Amsterdam UMC Location Vrije Universiteit Amsterdam
Knut K Kolskar (Author) - University of Oslo
Bernd Kramer (Author) - University Hospital Heidelberg
Jonna Kuntsi (Author) - King's College London
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Luisa Lazaro (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Irina S Lebedeva (Author) - Mental Health Research Center of Russian Academy of Medical Sciences
Phil H Lee (Author) - Massachusetts General Hospital
Christine Lochner (Author) - Stellenbosch University
Marise W J Machielsen (Author) - Amsterdam UMC Location University of Amsterdam
Sophie Maingault (Author) - Université de Bordeaux
Nicholas G Martin (Author) - QIMR Berghofer Medical Research Institute
Ignacio Martinez-Zalacain (Author) - Bellvitge University Hospital
David Mataix-Cols (Author) - Karolinska Institutet
Bernard Mazoyer (Author) - Université de Bordeaux
Brenna C McDonald (Author) - Indiana University
Colm McDonald (Author) - Ollscoil na Gaillimhe – University of Galway
Andrew M McIntosh (Author) - University of Edinburgh
Katie L McMahon (Author) - Queensland University of Technology
Genevieve McPhilemy (Author) - Ollscoil na Gaillimhe – University of Galway
Dennis van der Meer (Author) - University of Oslo
Jose M Menchon (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Jilly Naaijen (Author) - Radboud University Medical Center
Lars Nyberg (Author) - Umeå University
Jaap Oosterlaan (Author) - Amsterdam UMC Location Vrije Universiteit Amsterdam
Yannis Paloyelis (Author) - King's College London
Paul Pauli (Author) - University of Würzburg
Giulio Pergola (Author) - University of Bari Aldo Moro
Edith Pomarol-Clotet (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Maria J Portella (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Joaquim Radua (Author) - Karolinska Institutet
Andreas Reif (Author) - University Hospital Frankfurt
Genevieve Richard (Author) - University of Oslo
Joshua L Roffman (Author) - Harvard Medical School
Pedro G P Rosa (Author) - University of Sao Paulo
Matthew D Sacchet (Author) - Harvard Medical School
Perminder S Sachdev (Author) - UNSW Australia
Raymond Salvador (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Salvador Sarro (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Theodore D Satterthwaite (Author) - University of Pennsylvania
Andrew J Saykin (Author) - Indiana University
Mauricio H Serpa (Author) - University of Sao Paulo
Kang Sim (Author) - Institute of Mental Health
Andrew Simmons (Author) - King's College London
Jordan W Smoller (Author) - Massachusetts General Hospital
Iris E Sommer (Author) - University Medical Center Groningen
Carles Soriano-Mas (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Dan J Stein (Author) - University of Cape Town
Lachlan T Strike (Author) - The University of Queensland
Philip R Szeszko (Author) - Icahn School of Medicine at Mount Sinai
Henk S Temmingh (Author) - University of Cape Town
Sophia I Thomopoulos (Author) - University of Southern California
Julian N Trollor (Author) - UNSW Australia
Alexander S Tomyshev (Author) - Mental Health Research Center of Russian Academy of Medical Sciences
Anne Uhlmann (Author) - University of Cape Town
Ilya M Veer (Author) - Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Dick J Veltman (Author) - Amsterdam UMC Location Vrije Universiteit Amsterdam
Aristotle Voineskos (Author) - University of Toronto
Henry Völzke (Author) - Universität Greifswald
Henrik Walter (Author) - Charité
Lei Wang (Author) - Northwestern University
Wang Yang (Author) - Medical College of Wisconsin
Bernd Weber (Author) - University Hospital Bonn
Wei Wen (Author) - UNSW Australia
John D West (Author) - Indiana University
Lars T Westlye (Author) - University of Oslo
Heather C Whalley (Author) - University of Edinburgh
Steven C R Williams (Author) - King's College London
Katharina Wittfeld (Author) - Universität Greifswald
Daniel H Wolf (Author) - University of Pennsylvania
Margaret J Wright (Author) - The University of Queensland
Yuliya N Yoncheva (Author) - NYU Langone Health
Marcus V Zanetti (Author) - University of Sao Paulo
Georg C Ziegler (Author) - University of Würzburg
Greig I de Zubicaray (Author) - Queensland University of Technology
Paul M Thompson (Author) - University of Southern California
Eveline A Crone (Author) - Leiden University
Sophia Frangou (Author) - Icahn School of Medicine at Mount Sinai
Christian K Tamnes (Author) - University of Oslo
Publication details: Human Brain Mapping, Vol.43(1), pp.470-499
Publisher: John Wiley & Sons, Inc.
Date published: 2022
DOI: 10.1002/hbm.25204
ISSN: 1097-0193
PMID: 33044802; PMC8675415
Copyright note: © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99482297102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neuroimaging; Neurosciences; Radiology, Nuclear Medicine & Medical Imaging

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