Journal article
Greater Time in Bed and Less Physical Activity Associate With Poorer Cognitive Functioning Performance in Huntington's Disease
Neuropsychology, Vol.35(6), pp.656-667
2021
PMID: 34292025
Abstract
Objective: This study aimed to investigate how sleep and physical activity habits related to cognitive functioning, in naturalistic settings, in early Huntington's disease (HD). Method: Forty-two participants with the expanded HD repeat (20 manifest, 22 premanifest) and 29 healthy controls wore Fitbit One sleep and activity monitors for 7 days and 7 nights. They used a smartphone application to complete daily sleep and activity diaries, sleep and mood inventories, and a brief battery of cognitive tests, which were completed on Day 8 of the study. All data were collected in naturalistic home and community settings. Results: Amongst participants with the expanded HD repeat, greater time spent in bed, measured by Fitbit, was associated with poorer accuracy and response speed on a test of visual memory, whereas lower levels of physical activity, measured by Fitbit, were associated with poorer accuracy on a test involving aworking memory component. Neither time in bed nor physical activity is associated with a test of psychomotor speed. Groups were mostly similar across a range of Fitbit and self-report measures of sleep and physical activity, although the Manifest-HD group spent more time in bed than the Premanifest-HD and Healthy Control groups and had better self-reported sleep quality and more self-reported time spent sitting than the Healthy Control group and the Premanifest-HD group, respectively. Conclusions: Sleep timing and physical activity relate to cognitive functioning in HD and may be important targets for management in behavioral intervention studies aimed at improving cognition in HD.
Details
- Title
- Greater Time in Bed and Less Physical Activity Associate With Poorer Cognitive Functioning Performance in Huntington's Disease
- Authors
- Brendan McLaren (Author) - Monash UniversitySean P. A. Drummond (Author) - HologicYifat Glikmann-Johnston (Author) - Monash UniversityClement Loy (Author) - University of SydneyMark A. Bellgrove (Author) - Monash UniversityJulie C. Stout (Author) - Australian Regenerative Medicine InstituteSophie C. Andrews (Corresponding Author) - Monash University
- Publication details
- Neuropsychology, Vol.35(6), pp.656-667
- Publisher
- American Psychological Association
- DOI
- 10.1037/neu0000757
- ISSN
- 1931-1559
- PMID
- 34292025
- Organisation Unit
- Thompson Institute; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99659597702621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Neurosciences
- Psychology
- Psychology, Clinical
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Source: InCites