Gold nanorods embedded in polymeric film for killing bacteria by generating reactive oxygen species with light

Francesco Rossi; Nguyen Thi Kim Thanh; Xuai Du Su

doi:10.1021/acsabm.9b00343

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Gold nanorods embedded in polymeric film for killing bacteria by generating reactive oxygen species with light

Journal article

Open access

Peer reviewed

Gold nanorods embedded in polymeric film for killing bacteria by generating reactive oxygen species with light

Francesco Rossi, Nguyen Thi Kim Thanh and Xuai Du Su

ACS Applied Bio Materials, Vol.2(7), pp.3059-3067

2019

DOI: https://doi.org/10.1021/acsabm.9b00343

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Abstract

antibacterial film

sterilization

light activated

nanorods

nanomaterials

noncontact disinfection

For the first time, anisotropic gold nanorods (AuNRs) were embedded with a photosensitizer dye (crystal violet) in polyurethane (PU) matrix to create the effective antimicrobial film, capable of killing gram negative bacteria on its surface when exposed to white light. The dye, when activated with white light, interact with the AuNRs, to generate reactive oxygen species (ROS) which kill bacteria. With a proper control of the aspect ratio (2.1-2.4) and coating of the AuNRs, the film can be tuned to reduce the bacteria population of one to four orders of magnitude (1-log to 4-log) under 11 klux of light, for an exposure to light between 1 to 3 h. Particularly it could reduce 104 cfu/cm2 to the level of 1 - 5 cfu/cm2 in 3 h of light exposure. This was a desired performance for use in hospital surfaces. In addition, the system showed antimicrobial effect only when exposed to light which eliminated the concern for a cumulative toxic effect on subjects exposed to the material for a long period of time and limits the time given to the bacteria to develop resistance against the system. Furthermore, this process of sterilization could be carried out by a commercially available white light lamp, which when in use did not interrupt the normal routine operation of the environment.

Details

Title: Gold nanorods embedded in polymeric film for killing bacteria by generating reactive oxygen species with light
Authors: Francesco Rossi (Author) - University College London, United Kingdom
Nguyen Thi Kim Thanh (Author) - UCL Healthcare Biomagnetic and Nanomaterials Laboratory, United Kingdom
Xuai Du Su (Author) - University of the Sunshine Coast - School of Engineering & Science
Publication details: ACS Applied Bio Materials, Vol.2(7), pp.3059-3067
Publisher: American Chemical Society
Date published: 2019
DOI: 10.1021/acsabm.9b00343
ISSN: 2576-6422
Copyright note: This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99451346102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Materials Science, Biomaterials; Nanoscience & Nanotechnology

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