Journal article
Gold nanorods embedded in polymeric film for killing bacteria by generating reactive oxygen species with light
ACS Applied Bio Materials, Vol.2(7), pp.3059-3067
2019
Abstract
For the first time, anisotropic gold nanorods (AuNRs) were embedded with a photosensitizer dye (crystal violet) in polyurethane (PU) matrix to create the effective antimicrobial film, capable of killing gram negative bacteria on its surface when exposed to white light. The dye, when activated with white light, interact with the AuNRs, to generate reactive oxygen species (ROS) which kill bacteria. With a proper control of the aspect ratio (2.1-2.4) and coating of the AuNRs, the film can be tuned to reduce the bacteria population of one to four orders of magnitude (1-log to 4-log) under 11 klux of light, for an exposure to light between 1 to 3 h. Particularly it could reduce 104 cfu/cm2 to the level of 1 - 5 cfu/cm2 in 3 h of light exposure. This was a desired performance for use in hospital surfaces. In addition, the system showed antimicrobial effect only when exposed to light which eliminated the concern for a cumulative toxic effect on subjects exposed to the material for a long period of time and limits the time given to the bacteria to develop resistance against the system. Furthermore, this process of sterilization could be carried out by a commercially available white light lamp, which when in use did not interrupt the normal routine operation of the environment.
Details
- Title
- Gold nanorods embedded in polymeric film for killing bacteria by generating reactive oxygen species with light
- Authors
- Francesco Rossi (Author) - University College London, United KingdomNguyen Thi Kim Thanh (Author) - UCL Healthcare Biomagnetic and Nanomaterials Laboratory, United KingdomXuai Du Su (Author) - University of the Sunshine Coast - School of Engineering & Science
- Publication details
- ACS Applied Bio Materials, Vol.2(7), pp.3059-3067
- Publisher
- American Chemical Society
- Date published
- 2019
- DOI
- 10.1021/acsabm.9b00343
- ISSN
- 2576-6422; 2576-6422
- Copyright note
- This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99451346102621
- Output Type
- Journal article
- Research Statement
- false
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- Web Of Science research areas
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology
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