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Going Beyond Host Defence Peptides Horizons of Chemically Engineered Peptides for Multidrug-Resistant Bacteria1.20 MB
Published VersionCC BY-NC V4.0, Open Access
Journal article
Going Beyond Host Defence Peptides: Horizons of Chemically Engineered Peptides for Multidrug-Resistant Bacteria
BioDrugs, Vol.37(5), pp.607-623
2023
PMID: 37300748
Appears in UniSC Supported Open Access Outputs
Abstract
Multidrug-resistant (MDR) bacteria are considered a health threat worldwide, and this problem is set to increase over the decades. The ESKAPE, a group of six pathogens including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. is the major source of concern due to their high death incidence and nosocomial acquired infection. Host defence peptides (HDPs) are a class of ribosomally synthesised peptides that have shown promising results in combating MDR, including the ESKAPE group, in- and outside bacterial biofilms. However, their poor pharmacokinetics in physiological mediums may impede HDPs from becoming viable clinical candidates. To circumvent this problem, chemical engineering of HDPs has been seen as an emergent approach to not only improve their pharmacokinetics but also their efficacy against pathogens. In this review, we explore several chemical modifications of HDPs that have shown promising results, especially against ESKAPE pathogens, and provide an overview of the current findings with respect to each modification.
Details
- Title
- Going Beyond Host Defence Peptides: Horizons of Chemically Engineered Peptides for Multidrug-Resistant Bacteria
- Authors
- Bernardo Cavallazzi Sebold (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringJunjie Li (Author) - Guangdong Pharmaceutical UniversityGuoying Ni (Author) - University of the Sunshine Coast, Queensland, Centre for BioinnovationQuanlan Fu (Author) - Guangdong Pharmaceutical UniversityHejie Li (Author) - University of the Sunshine Coast, Queensland, Centre for BioinnovationXiaosong Liu (Corresponding Author) - Guangdong Pharmaceutical UniversityTianfang Wang (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and Engineering
- Publication details
- BioDrugs, Vol.37(5), pp.607-623
- Publisher
- Adis International Ltd.
- Date published
- 2023
- DOI
- 10.1007/s40259-023-00608-3
- ISSN
- 1179-190X; 1173-8804
- PMID
- 37300748
- Copyright note
- This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
- Grant note
- 2019A008/ Foshan First People’s Hospital 2020A1515010855/ National Science Foundation of Guangdong province 31971355/ National Natural Science Foundation of China
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99735298502621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Immunology
- Oncology
- Pharmacology & Pharmacy
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