Journal article
Glycogenic hepatopathy associated with hepatic steatosis in type 1 diabetes
Journal of Diabetes and its Complications, Vol.38(11), pp.1-7
2024
PMID: 39306876
Abstract
Aims
Glycogenic hepatopathy is associated with significant psychosocial consequences and health costs. Metabolic Dysfunction-Associated Steatotic Liver Disease and glycogenic hepatopathy are frequently confused as “fatty liver” when seen on ultrasonography. We wished to examine liver fat and glycogen content in groups defined based on metabolic and liver disease phenotypes.
Methods
This case-control study undertaken in a tertiary hospital used nuclear proton magnetic resonance spectroscopy (1H-MRS) to examine liver fat and glycogen content in five clinical groups, each containing five participants: 1. type 1 diabetes with glycogenic hepatopathy, 2. satisfactorily controlled type 1 diabetes with no liver disease, 3. poorly controlled type 1 diabetes without liver disease, 4. a control group of body mass index- and age-matched individuals without diabetes or liver disease, and 5. hepatic steatosis.
Results
Fat content was highest in the hepatic steatosis (median 15.4 %, IQR 10.0–19.3) and glycogenic hepatopathy (median 6.5 %, IQR 4.5–9.1) groups and compared to both of these groups was lower in the control group (median 1.0 %, IQR 0.7–1.1, p 0.002 and 0.022), the T1DM group with satisfactory control (median 0.3 %, IQR 0.2–0.6, p < 0.001 and <0.001), and the T1DM group with poor control without liver disease (median 1.1 %, IQR 0.9–1.1, p 0.001 and 0.012).
No participants from the type 1 diabetes poor control, type 1 diabetes satisfactory control or the no diabetes groups had 1H-MRS-diagnosed hepatic steatosis.
1H-MRS glycogen content could not be interpreted in the majority of those with glycogenic hepatopathy because of interference from the fat signal.
Conclusions
In cases diagnosed with glycogenic hepatopathy there may be significant concomitant fat accumulation, compounding the already elevated cardiovascular risk in this cohort.
The technique of 1H-MRS has not been demonstrated to be useful for diagnosing glycogenic hepatopathy.
Details
- Title
- Glycogenic hepatopathy associated with hepatic steatosis in type 1 diabetes
- Authors
- Stephanie Teasdale (Corresponding Author) - Mater Health ServicesXin Dong - Translational Research InstituteAlison Griffin - QIMR Berghofer Medical Research InstitutePaul James Clark - Mater Health ServicesJanelle Nisbet - Mater Health ServicesAdam Morton - Mater Health ServicesLiza Phillips - Mater Health ServicesMitchell Anthony Sullivan - University of QueenslandGraham Galloway - Translational Research Institute
- Publication details
- Journal of Diabetes and its Complications, Vol.38(11), pp.1-7
- Publisher
- Elsevier Inc.
- Date published
- 2024
- DOI
- 10.1016/j.jdiacomp.2024.108870
- ISSN
- 1873-460X
- PMID
- 39306876
- Data Availability
- Data available on request from the authors.
- Grant note
- M. A. S. is supported by an Advance Queensland Industry Research Fellowship and Mater Foundation (Equity Trustees and the L G McCallam Est and George Weaber Trusts).
- Organisation Unit
- School of Health - Biomedicine; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991136705002621
- Output Type
- Journal article
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