Journal article
Glycogen structure in type 1 diabetic mice: Towards understanding the origin of diabetic glycogen molecular fragility
International Journal of Biological Macromolecules, Vol.128, pp.665-672
2019
PMID: 30708007
Abstract
Glycogen is a complex branched glucose polymer. Liver glycogen in db/db mouse, a type-2 diabetic mouse model, has been found to be more molecularly fragile than in healthy mice. Size-exclusion chromatography was employed in this study to investigate the molecular structure of liver glycogen in two types of type 1 diabetic mouse models (NOD and C57BL/6J mice), sacrificed at various times throughout the diurnal cycle, and the fragility of liver glycogen after exposure to a hydrogen-bond disruptor were tested. Type 1 diabetic mice exhibit a similar glycogen fragility with that observed for db/db mice. This eliminates many of the potential causes for glycogen molecular fragility; the most likely explanation is that it is caused by high blood-glucose level and/or insulin deficiency, both phenotypes being common to both type 1 and type 2 diabetic mice. This result suggests ways towards new drug targets for the management of diabetes.
Details
- Title
- Glycogen structure in type 1 diabetic mice: Towards understanding the origin of diabetic glycogen molecular fragility
- Authors
- Zhenxia Hu - Wuhan UniversityEnpeng Li - Yangzhou UniversityMitchell A Sullivan - University of QueenslandXinle Tan - University of QueenslandBin Deng - Huazhong University of Science and TechnologyRobert G Gilbert (Corresponding Author) - University of QueenslandCheng Li (Corresponding Author) - Yangzhou University
- Publication details
- International Journal of Biological Macromolecules, Vol.128, pp.665-672
- Publisher
- Elsevier BV
- Date published
- 2019
- DOI
- 10.1016/j.ijbiomac.2019.01.186
- ISSN
- 1879-0003
- PMID
- 30708007
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035096002621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Applied
- Polymer Science
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