Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

Robert J Harvey; B K Yee

doi:10.1038/nrd3893

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Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

Journal article

Peer reviewed

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

Robert J Harvey and B K Yee

Nature Reviews Drug Discovery, Vol.12(11), pp.866-885

2013

DOI: https://doi.org/10.1038/nrd3893

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Abstract

2 chloro n [alpha (2 piperidinyl)benzyl] 3 trifluoromethylbenzamide

6 dichloro 3 (2 oxo 1 phenyl 3 pyrrolidinylidenemethyl) 1h indole 2 carboxylic acid

amg 747

amphetamine

bitopertin

clonazepam

clozapine

dextro serine

dopamine

dopamine 2 recept

Glycine transporters are endogenous regulators of the dual functions of glycine, which acts as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of neuronal excitation mediated by NMDA (N-methyl-D-aspartate) receptors at glutamatergic synapses. The two major subtypes of glycine transporters, GlyT1 and GlyT2, have been linked to the pathogenesis and/or treatment of central and peripheral nervous system disorders, including schizophrenia and related affective and cognitive disturbances, alcohol dependence, pain, epilepsy, breathing disorders and startle disease (also known as hyperekplexia). This Review examines the rationale for the therapeutic potential of GlyT1 and GlyT2 inhibition, and surveys the latest advances in the biology of glycine reuptake and transport as well as the drug discovery and clinical development of compounds that block glycine transporters. © 2013 Macmillan Publishers Limited. All rights reserved.

Details

Title: Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain
Authors: Robert J Harvey (Author) - University College London, United Kingdom
B K Yee (Author) - Legacy Research Institute, United States
Publication details: Nature Reviews Drug Discovery, Vol.12(11), pp.866-885
Publisher: Nature Publishing Group
Date published: 2013
DOI: 10.1038/nrd3893
ISSN: 1474-1776
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450451402621
Output Type: Journal article

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