GlyR α3: An Essential Target for Spinal PGE2-Mediated Inflammatory Pain Sensitization

Robert J Harvey; U B Depner; H Wässle; S Ahmadi; C Heindl; H Reinold; T G Smart; K Harvey; B Schütz; O M Abo-Salem; A Zimmer; P Poisbeau; H Welzl; D P Wolfer; H Betz; H U Zeilhofer; U Müller

doi:10.1126/science.1094925

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GlyR α3: An Essential Target for Spinal PGE2-Mediated Inflammatory Pain Sensitization

Journal article

Peer reviewed

GlyR α3: An Essential Target for Spinal PGE2-Mediated Inflammatory Pain Sensitization

Robert J Harvey, U B Depner, H Wässle, S Ahmadi, C Heindl, H Reinold, T G Smart, K Harvey, B Schütz, O M Abo-Salem, …

Science, Vol.304(5672), pp.884-887

2004

DOI: https://doi.org/10.1126/science.1094925

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Abstract

biochemistry

drug therapy

neurology

pain sensitization

phosphorylation

Prostaglandin E2 (PGE2) is a crucial, mediator of inflammatory pain sensitization. Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization. We show that GlyR α3 is distinctly expressed in superficial layers of the spinal cord dorsal horn. Mice deficient in GlyR α3 not only lack the inhibition of glycinergic neurotransmission by PGE2 seen in wild-type mice but also show a reduction in pain sensitization induced by spinal, PGE2 injection or peripheral, inflammation. Thus, GlyR α3 may provide a previously unrecognized molecular target in pain therapy.

Details

Title: GlyR α3: An Essential Target for Spinal PGE2-Mediated Inflammatory Pain Sensitization
Authors: Robert J Harvey (Author) - School of Pharmacy, United Kingdom
U B Depner (Author) - Universität Erlangen-Nürnberg, Germany
H Wässle (Author) - Max-Planck-Institut für Hirnforschung, Germany
S Ahmadi (Author) - Universität Erlangen-Nürnberg, Germany
C Heindl (Author) - Universität Erlangen-Nürnberg, Germany
H Reinold (Author) - Universität Erlangen-Nürnberg, Germany
T G Smart (Author) - University College London, United Kingdom
K Harvey (Author) - School of Pharmacy, United Kingdom
B Schütz (Author) - Universitätsklinikum Bonn, Germany
O M Abo-Salem (Author) - Universitätsklinikum Bonn, Germany
A Zimmer (Author) - Universitätsklinikum Bonn, Germany
P Poisbeau (Author) - Université Louis Pasteur, France
H Welzl (Author) - Universität Zürich-Irchel, Switzerland
D P Wolfer (Author) - Universität Zürich-Irchel, Switzerland
H Betz (Author) - Max-Planck-Institut für Hirnforschung, Germany
H U Zeilhofer (Author) - Universität Erlangen-Nürnberg, Germany
U Müller (Author) - Max-Planck-Institut für Hirnforschung, Germany
Publication details: Science, Vol.304(5672), pp.884-887
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.1094925
ISSN: 0036-8075
Organisation Unit: School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy; Centre for Bioinnovation; University of the Sunshine Coast, Queensland; School of Health
Language: English
Record Identifier: 99450803502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neurosciences

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