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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Glucose and glycogen in the diabetic kidney: Heroes or villains?
EBioMedicine, Vol.47, pp.590-597
2019
PMID: 31405756
Abstract
Glucose metabolism in the kidney is currently foremost in the minds of nephrologists, diabetologists and researchers globally, as a result of the outstanding success of SGLT2 inhibitors in reducing renal and cardiovascular disease in individuals with diabetes. However, these exciting data have come with the puzzling but fascinating paradigm that many of the beneficial effects on the kidney and cardiovascular system seem to be independent of the systemic glucose lowering actions of these agents. This manuscript places into context an area of research highly relevant to renal glucose metabolism, that of glycogen accumulation and metabolism in the diabetic kidney. Whether the glycogen that abnormally accumulates is pathological (the villain), is somehow protective (the hero) or is inconsequential (the bystander) is a research question that may provide insight into the link between diabetes and diabetic kidney disease.
Details
- Title
- Glucose and glycogen in the diabetic kidney: Heroes or villains?
- Authors
- Mitchell A Sullivan (Corresponding Author) - Translational Research InstituteJosephine M Forbes (Corresponding Author) - The University of Queensland
- Publication details
- EBioMedicine, Vol.47, pp.590-597
- Publisher
- The Lancet Publishing Group
- Date published
- 2019
- DOI
- 10.1016/j.ebiom.2019.07.067
- ISSN
- 2352-3964
- PMID
- 31405756
- Copyright note
- © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035095802621
- Output Type
- Journal article
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