Gephyrin: where do we stand, where do we go?

J M Fritschy; Robert J Harvey; G Schwarz

doi:10.1016/j.tins.2008.02.006

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Gephyrin: where do we stand, where do we go?

Journal article

Peer reviewed

Gephyrin: where do we stand, where do we go?

J M Fritschy, Robert J Harvey and G Schwarz

Trends in Neurosciences, Vol.31(5), pp.257-264

2008

DOI: https://doi.org/10.1016/j.tins.2008.02.006

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Abstract

gephyrin

glycine receptor

messenger RNA

Gephyrin is a multifunctional protein responsible for molybdenum cofactor synthesis and the clustering of glycine and GABAA receptors at inhibitory synapses. Based on the structure of its two conserved domains, G and E, gephyrin is thought to form a hexagonal lattice serving as a scaffold for accessory proteins at postsynaptic sites. However, important aspects of gephyrin gene expression, protein structure and regulation, as well as the role of gephyrin in synapse formation and plasticity, remain poorly understood. Here we review the current state of knowledge about gephyrin, highlighting new research avenues based on a different structural model and a revised nomenclature for gephyrin splice variants. Unraveling the biology of gephyrin will further our understanding of glycinergic and GABAergic synapses in health and disease. © 2008 Elsevier Ltd. All rights reserved.

Details

Title: Gephyrin: where do we stand, where do we go?
Authors: J M Fritschy (Author) - University of Zurich, Switzerland
Robert J Harvey (Author) - School of Pharmacy, United Kingdom
G Schwarz (Author) - University of Cologne, Germany
Publication details: Trends in Neurosciences, Vol.31(5), pp.257-264
Publisher: Elsevier Ltd.
Date published: 2008
DOI: 10.1016/j.tins.2008.02.006
ISSN: 0166-2236
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450931302621
Output Type: Journal article

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Web Of Science research areas: Neurosciences

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