Geographic consistency in dominant, non-typeable Haemophilus influenzae genotypes colonising four distinct Australian paediatric groups: a cohort study

Heidi C Smith-Vaughan; Jemima Beissbarth; Jacinta Bowman; Kim M Hare; Erin P Price; Janessa Pickering; Deborah Lehmann; Anne B Chang; Peter S Morris; Robyn L Marsh; Amanda J Leach

doi:10.1186/s41479-016-0013-y

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Geographic consistency in dominant, non-typeable Haemophilus influenzae genotypes colonising four distinct Australian paediatric groups: a cohort study

Journal article

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Geographic consistency in dominant, non-typeable Haemophilus influenzae genotypes colonising four distinct Australian paediatric groups: a cohort study

Heidi C Smith-Vaughan, Jemima Beissbarth, Jacinta Bowman, Kim M Hare, Erin P Price, Janessa Pickering, Deborah Lehmann, Anne B Chang, Peter S Morris, Robyn L Marsh, …

Pneumonia, Vol.8, 13

2016

DOI: https://doi.org/10.1186/s41479-016-0013-y

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Abstract

Other Medical and Health Sciences

non-typeable Haemophilus influenzae

genotyping

carriage

paediatric

PCR-ribotyping

Non-typeable Haemophilus influenzae (NTHi)-associated ear and respiratory diseases (including pneumonia) represent a major health burden in many parts of the world. NTHi strains retrieved from the upper airways commonly reflect those found in the lower airways. Despite growing genomic and genotyping data on NTHi, there remains a limited understanding of global and regional NTHi population structures. The aim of this study was to determine whether nasopharyngeal carriage in four Australian paediatric groups at varying risk of NTHi colonisation was dominated by the same NTHi genotypes. Genotyping data generated by PCR-ribotyping were evaluated for 3070 NTHi isolates colonising the nasopharynges of Aboriginal and non-Aboriginal children enrolled in four longitudinal studies in three separate urban and remote regions of Australia. Several NTHi PCR-ribotypes dominated in nasopharyngeal carriage, irrespective of study setting. Principal coordinates analysis confirmed a cluster of common PCR-ribotypes among all cohorts. In conclusion, we identified dominant PCR-ribotypes common to geographically disparate Australian paediatric populations. Future genomic analyses will shed further light on the precise factors underlying the dominance of certain NTHi strains in nasopharyngeal carriage.

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Title: Geographic consistency in dominant, non-typeable Haemophilus influenzae genotypes colonising four distinct Australian paediatric groups: a cohort study
Authors: Heidi C Smith-Vaughan (Author) - Griffith University
Jemima Beissbarth (Author) - Charles Darwin University
Jacinta Bowman (Author) - PathWest Laboratory Medicine
Kim M Hare (Author) - Charles Darwin University
Erin P Price (Author) - Charles Darwin University
Janessa Pickering (Author) - University of Western Australia
Deborah Lehmann (Author) - University of Western Australia
Anne B Chang (Author) - Charles Darwin University
Peter S Morris (Author) - Charles Darwin University
Robyn L Marsh (Author) - Charles Darwin University
Amanda J Leach (Author) - Charles Darwin University
Publication details: Pneumonia, Vol.8, 13; 6
Publisher: BioMed Central Ltd.
Date published: 2016
DOI: 10.1186/s41479-016-0013-y
ISSN: 2200-6133
Copyright note: Copyright © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99451174402621
Output Type: Journal article

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Web Of Science research areas: Respiratory System

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