Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Renfu Shao; See article text for complete listing of authors.

doi:10.1038/ncomms10507

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Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Journal article

Open access

Peer reviewed

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Renfu Shao and See article text for complete listing of authors.

Nature Communications, Vol.7, pp.1-13

2016

DOI: https://doi.org/10.1038/ncomms10507

PMCID: PMC4748124

PMID: 26856261

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Abstract

Ixodes scapularis

Lyme disease

Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ~57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.

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Title: Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Authors: Renfu Shao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
See article text for complete listing of authors. (Author)
Publication details: Nature Communications, Vol.7, pp.1-13
Publisher: Nature Publishing Group
Date published: 2016
DOI: 10.1038/ncomms10507
ISSN: 2041-1723
PMID: 26856261; PMC4748124
Copyright note: Copyright © 2016 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Grants: Evolution and function of fragmented animal mitochondrial genomes, DP120100240, Food Standards Australia New Zealand
Organisation Unit: School of Science and Engineering - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99449475602621
Output Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology

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