Journal article
Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Nature Communications, Vol.7, pp.1-13
2016
PMCID: PMC4748124
PMID: 26856261
Abstract
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ~57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
Details
- Title
- Genomic insights into the Ixodes scapularis tick vector of Lyme disease
- Authors
- Monika Gulia-Nuss - University of Nevada, RenoAndrew B Nuss - University of Nevada, RenoJason M Meyer - Purdue University West LafayetteDaniel E Sonenshine - Old Dominion UniversityR Michael Roe - North Carolina State UniversityRobert M Waterhouse - University of GenevaDavid B Sattelle - University of ManchesterJosé de la Fuente - Oklahoma State UniversityJose M Ribeiro - National Institute of Allergy and Infectious DiseasesKarine Megy - University of CambridgeJyothi Thimmapuram - Purdue University West LafayetteJason R Miller - J. Craig Venter InstituteBrian P Walenz - J. Craig Venter InstituteSergey Koren - National Institutes of HealthJessica B Hostetler - National Institute of Allergy and Infectious DiseasesMathangi Thiagarajan - Leidos Biomedical Research Inc. (United States)Vinita S Joardar - National Institutes of HealthLinda I Hannick - Frederick National Laboratory for Cancer ResearchShelby Bidwell - National Institutes of HealthMartin P HammondSarah Young - Broad InstituteQiandong Zeng - Broad InstituteJenica L Abrudan - University of Nevada, Las VegasFrancisca C Almeida - Universitat de BarcelonaNieves Ayllón - Instituto de Investigación en Recursos CinegéticosKetaki Bhide - Purdue University West LafayetteBrooke W Bissinger - AgBiome (United States)Elena Bonzon-Kulichenko - Spanish National Centre for Cardiovascular ResearchSteven D Buckingham - University of OxfordDaniel R Caffrey - University of Massachusetts Chan Medical SchoolMelissa J Caimano - University of ConnecticutVincent Croset - University of OxfordTimothy Driscoll - West Virginia UniversityDon Gilbert - Indiana UniversityJoseph J Gillespie - University of Maryland, BaltimoreGloria I Giraldo-Calderón - Purdue University West LafayetteJeffrey M Grabowski - National Institute of Allergy and Infectious DiseasesDavid Jiang - Virginia TechSayed M S Khalil - Agricultural Genetic Engineering Research InstituteDonghun Kim - Kansas State UniversityKatherine M Kocan - Oklahoma State UniversityJuraj Koči - University of Maryland, BaltimoreRichard J Kuhn - Purdue University West LafayetteTimothy J Kurtti - Islamic University of MinnesotaKristin Lees - National University of SingaporeEmma G Lang - Purdue University West LafayetteRyan C Kennedy - University of California, San FranciscoHyeogsun Kwon - Iowa State UniversityRushika Perera - Colorado State UniversityYumin Qi - Virginia TechJustin D Radolf - University of ConnecticutJoyce M Sakamoto - Pennsylvania State UniversityAlejandro Sánchez-Gracia - Universitat de BarcelonaMaiara S Severo - National Institutes of HealthNeal Silverman - University of Massachusetts Chan Medical SchoolLadislav Šimo - Kansas State UniversityMarta Tojo - University of CambridgeCristian Tornador - Universitat Pompeu FabraJanice P Van Zee - Purdue University West LafayetteJesús Vázquez - Spanish National Centre for Cardiovascular ResearchFilipe G Vieira - Universitat de BarcelonaMargarita Villar - Instituto de Investigación en Recursos CinegéticosAdam R Wespiser - University of Massachusetts Chan Medical SchoolYunlong Yang - Texas A&M UniversityJiwei Zhu - North Carolina State UniversityPeter Arensburger - California State Polytechnic UniversityPatricia V Pietrantonio - Texas A&M UniversityStephen C Barker - The University of QueenslandRenfu Shao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringSee article text for complete list of remaining 24 authors (Author)
- Publication details
- Nature Communications, Vol.7, pp.1-13
- Publisher
- Nature Publishing Group
- Date published
- 2016
- DOI
- 10.1038/ncomms10507
- ISSN
- 2041-1723
- PMID
- 26856261; PMC4748124
- Copyright note
- Copyright © 2016 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Organisation Unit
- School of Science and Engineering - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99449475602621
- Output Type
- Journal article
Metrics
97 File views/ downloads
1230 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
Highly Cited Paper
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: SDGs from InCites