Genomic Insights Into the Melioidosis Pathogen, Burkholderia pseudomallei

Erin P Price; Bart J Currie; Derek S Sarovich

doi:10.1007/s40475-017-0111-9

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Genomic Insights Into the Melioidosis Pathogen, Burkholderia pseudomallei

Journal article

Peer reviewed

Genomic Insights Into the Melioidosis Pathogen, Burkholderia pseudomallei

Erin P Price, Bart J Currie and Derek S Sarovich

Current Tropical Medicine Reports, Vol.4(3), pp.95-102

2017

DOI: https://doi.org/10.1007/s40475-017-0111-9

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Abstract

Burkholderia pseudomallei

genomics

evolution

phylogeography

melioidosis

antibiotic resistance

Purpose of Review: Genomics has fundamentally transformed our understanding of infectious diseases. Here, we provide an overview of the insights gained from genomic investigations of the melioidosis-causing pathogen, Burkholderia pseudomallei. Recent Findings: B. pseudomallei has a large and complex genome that encodes an impressive array of virulence factors, some of which are variably present. Despite frequent lateral gene transfer, phylogenomics resolves B. pseudomallei populations to the continental level, enabling strain source tracing in non-endemic regions and shedding light on the origin and anthropogenic spread of B. pseudomallei populations across tropical and subtropical regions worldwide. Within-host evolution, outbreak point-sources and antibiotic resistance can now be rapidly elucidated using comparative genomic approaches. Summary: Genomics is an essential tool for understanding the phylogeography, transmission, evolution, virulence, epidemiology, and antibiotic resistance of B. pseudomallei. A shift towards more detailed characterization of genetic variation using RNA-Seq, Methyl-Seq, and genome-wide association studies will provide additional insights into this fascinating and deadly bacterium.

Details

Title: Genomic Insights Into the Melioidosis Pathogen, Burkholderia pseudomallei
Authors: Erin P Price (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Bart J Currie (Author) - Menzies School of Health Research
Derek S Sarovich (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Current Tropical Medicine Reports, Vol.4(3), pp.95-102
Publisher: Springer
Date published: 2017
DOI: 10.1007/s40475-017-0111-9
ISSN: 2196-3045
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99451139202621
Output Type: Journal article

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