Journal article
Genomewide DNA methylation analysis in combat veterans reveals a novel locus for PTSD
Acta Psychiatrica Scandinavica, Vol.136(5), pp.493-505
2017
PMID: 28795405
Abstract
Objective:
Epigenetic modifications such as DNA methylation may play a key role in the aetiology and serve as biomarkers for post-traumatic stress disorder (PTSD). We performed a genomewide analysis to identify genes whose DNA methylation levels are associated with PTSD.
Method:
A total of 211 individuals comprising Australian male Vietnam War veterans (n = 96) and males from a general population belonging to the Grady Trauma Project (n = 115) were included. Genomewide DNA methylation was performed from peripheral blood using the Illumina arrays. Data analysis was performed using generalized linear regression models.
Results:
Differential DNA methylation of 17 previously reported PTSD candidate genes was associated with PTSD symptom severity. Genomewide analyses revealed CpG sites spanning BRSK1, LCN8, NFG and DOCK2 genes were associated with PTSD symptom severity. We replicated the findings of DOCK2 in an independent cohort. Pathway analysis revealed that among the associated genes, genes within actin cytoskeleton and focal adhesion molecular pathways were enriched.
Conclusion:
These data highlight the role of DNA methylation as biomarkers of PTSD. The results support the role of previous candidates and uncover novel genes associated with PTSD, such as DOCK2. This study contributes to our understanding of the biological underpinnings of PTSD.
Details
- Title
- Genomewide DNA methylation analysis in combat veterans reveals a novel locus for PTSD
- Authors
- Divya Mehta (Author) - Queensland University of TechnologyDagmar Bruenig (Author) - Queensland University of TechnologyTania Carrillo-Roa (Author) - Max Planck Institute of PsychiatryBruce R Lawford (Author) - Queensland University of TechnologyWendy Harvey (Author) - Gallipoli Medical Research FoundationCharles Phillip Morris (Author) - Queensland University of TechnologyAlicia K Smith (Author) - Emory UniversityElisabeth B Binder (Author) - Max Planck Institute of PsychiatryRoss Young (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of Technology
- Publication details
- Acta Psychiatrica Scandinavica, Vol.136(5), pp.493-505
- Publisher
- Wiley-Blackwell Publishing, Inc.
- Date published
- 2017
- DOI
- 10.1111/acps.12778
- ISSN
- 1600-0447; 0001-690X
- PMID
- 28795405
- Copyright note
- Copyright (c) 2017 John Wiley & Sons. This is the peer reviewed version of the following article: Mehta, D, Bruenig, D, Carrillo-Roa, T, Lawford, B, Harvey, W, Morris, CP, Smith, AK, Binder, EB, Young, RMcD, Voisey, J. Genomewide DNA methylation analysis in combat veterans reveals a novel locus for PTSD, which has been published in final form at https://doi.org/10.1111/acps.12778. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550996502621
- Output Type
- Journal article
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