Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny

Laurence Don Wai Luu; Vasilli Kasimov; Samuel Phillips; Garry S. A. Myers; Martina Jelocnik

doi:10.3389/fcimb.2023.1178736

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Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny

Journal article

Open access

Peer reviewed

Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny

Laurence Don Wai Luu, Vasilli Kasimov, Samuel Phillips, Garry S. A. Myers and Martina Jelocnik

Frontiers in cellular and infection microbiology, Vol.13, pp.1-16

2023

DOI: https://doi.org/10.3389/fcimb.2023.1178736

PMCID: PMC10242142

PMID: 37287464

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Abstract

Chlamydia trachomatis

Chlamydiaceae

genome content

genomics

host tropism

next generation sequencing

tissue tropism

whole genome sequence

The genus Chlamydia contains important obligate intracellular bacterial pathogens to humans and animals, including C. trachomatis and C. pneumoniae. Since 1998, when the first Chlamydia genome was published, our understanding of how these microbes interact, evolved and adapted to different intracellular host environments has been transformed due to the expansion of chlamydial genomes. This review explores the current state of knowledge in Chlamydia genomics and how whole genome sequencing has revolutionised our understanding of Chlamydia virulence, evolution, and phylogeny over the past two and a half decades. This review will also highlight developments in multi-omics and other approaches that have complemented whole genome sequencing to advance knowledge of Chlamydia pathogenesis and future directions for chlamydial genomics.

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Title: Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny
Authors: Laurence Don Wai Luu (Author) - University of Technology Sydney
Vasilli Kasimov (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and Engineering
Samuel Phillips (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Garry S. A. Myers (Author) - University of Technology Sydney
Martina Jelocnik (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Publication details: Frontiers in cellular and infection microbiology, Vol.13, pp.1-16
Publisher: Frontiers Research Foundation
Date published: 2023
DOI: 10.3389/fcimb.2023.1178736
ISSN: 2235-2988
PMID: 37287464; PMC10242142
Copyright note: © 2023 Luu, Kasimov, Phillips, Myers and Jelocnik. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Grant note: University of Technology Sydney
Organisation Unit: University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99735298602621
Output Type: Journal article

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Web Of Science research areas: Immunology; Microbiology

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