Genetically encoded libraries and spider venoms as emerging sources for crop protective peptides

Elena Marone Fassolo; Shaodong Guo; Yachen Wang; Stefano Rosa; Volker Herzig

doi:10.1002/psc.3600

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Genetically encoded libraries and spider venoms as emerging sources for crop protective peptides

Journal article

Open access

Peer reviewed

Genetically encoded libraries and spider venoms as emerging sources for crop protective peptides

Elena Marone Fassolo, Shaodong Guo, Yachen Wang, Stefano Rosa and Volker Herzig

Journal of Peptide Science, Vol.30(9), pp.1-9

2024

DOI: https://doi.org/10.1002/psc.3600

PMID: 38623834

Appears in UniSC Supported Open Access Outputs

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Abstract

two‐hybrid assays

spider venom peptides

pesticides

crop protection

genetically encoded peptide libraries

antimicrobial peptides

bioinsecticides

Agricultural crops are targeted by various pathogens (fungi, bacteria, and viruses) and pests (herbivorous arthropods). Antimicrobial and insecticidal peptides are increasingly recognized as eco-friendly tools for crop protection due to their low propensity for resistance development and the fact that they are fully biodegradable. However, historical challenges have hindered their development, including poor stability, limited availability, reproducibility issues, high production costs, and unwanted toxicity. Toxicity is a primary concern because crop-protective peptides interact with various organisms of environmental and economic significance. This review focuses on the potential of genetically encoded peptide libraries like the use of two-hybrid-based methods for antimicrobial peptides identification and insecticidal spider venom peptides as two main approaches for targeting plant pathogens and pests. We discuss some key findings and challenges regarding the practical application of each strategy. We conclude that genetically encoded peptide library- and spider venom-derived crop protective peptides offer a sustainable and environmentally responsible approach for addressing modern crop protection needs in the agricultural sector.

Details

Title: Genetically encoded libraries and spider venoms as emerging sources for crop protective peptides
Authors: Elena Marone Fassolo - University of Milan
Shaodong Guo - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Yachen Wang - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Stefano Rosa - Northeastern University
Volker Herzig (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Publication details: Journal of Peptide Science, Vol.30(9), pp.1-9
Publisher: John Wiley & Sons Ltd.
Date published: 2024
DOI: 10.1002/psc.3600
ISSN: 1099-1387
PMID: 38623834
Copyright note: © 2024 The Authors. Journal of Peptide Science published by European Peptide Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Grants: Be(e) friendly venomous spiders! Novel biopesticides from arachnid venoms, FT190100482, Australian Research Council (Australia, Canberra) - ARC
Organisation Unit: School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 991014259202621
Output Type: Journal article

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