Genetic variation in group A streptococci

David J McMillan; K S Sriprakash; G S Chhatwal

doi:10.1016/j.ijmm.2007.02.007

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Genetic variation in group A streptococci

Journal article

Open access

Peer reviewed

Genetic variation in group A streptococci

David J McMillan, K S Sriprakash and G S Chhatwal

International Journal of Medical Microbiology, Vol.297(7-8), pp.525-532

2007

DOI: https://doi.org/10.1016/j.ijmm.2007.02.007

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Abstract

Medical Microbiology

group A streptococci

streptococcus pyogenes

comparative genomics

Group A streptococcus (GAS) is responsible for a range of human diseases that vary in their clinical manifestations and severity. While numerous virulence factors have been described, the way these factors interact to promote different streptococcal diseases is less clear. In order to identify multifactorial relationships between GAS and the human host, novel high-throughput techniques such as microarrays are necessary. We have performed comparative studies using custom-designed virulence arrays to enhance our understanding of the high degree of genotypic variation that occurs in streptococci. This study has pointed to mobile genetic elements as the major agents that promote variation. Our results show that multiple combinations of genes might bring about similar clinical pictures. This adds further complexity to the intricate relationship between pathogen and host.

Details

Title: Genetic variation in group A streptococci
Authors: David J McMillan (Author) - Queensland Institute of Medical Research
K S Sriprakash (Author) - Queensland Institute of Medical Research
G S Chhatwal (Author) - Helmholtz Centre for Infection Research, Germany
Publication details: International Journal of Medical Microbiology, Vol.297(7-8), pp.525-532
Publisher: Urban & Fischer Verlag
Date published: 2007
DOI: 10.1016/j.ijmm.2007.02.007
ISSN: 1438-4221; 1438-4221
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450380102621
Output Type: Journal article
Research Statement: false

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Microbiology; Virology

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