Genetic linkage findings for DSM-IV nicotine withdrawal in two populations

M L Pergadia; A Agrawal; A Loukola; G W Montgomery; U Broms; S F Saccone; J C Wang; A A Todorov; K Heikklia; Dixie J Statham; A Henders; M Campbell; J Rice; R D Todd; A C Heath; A M Goate; L Peltonen; J Kaprio; N G Martin; P A F Madden

doi:10.1002/ajmg.b.30924

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Genetic linkage findings for DSM-IV nicotine withdrawal in two populations

Journal article

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Genetic linkage findings for DSM-IV nicotine withdrawal in two populations

M L Pergadia, A Agrawal, A Loukola, G W Montgomery, U Broms, S F Saccone, J C Wang, A A Todorov, K Heikklia, Dixie J Statham, …

American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol.150(7), pp.950-959

2009

DOI: https://doi.org/10.1002/ajmg.b.30924

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Abstract

linkage

nicotine

withdrawal

Nicotine withdrawal (NW) is both an important contributor to difficulty quitting cigarettes and because of mood-related withdrawal symptoms a problem of particular relevance to psychiatry. Twin-studies suggest that genetic factors influence NW (heritability = 45%). Only one previous linkage study has published findings on NW [Swan et al. (2006); Am J Med Genet Part B 141B:354-360; LOD = 2.7; Chr. 6 at 159 cM]. As part of an international consortium, genome-wide scans (using over 360 autosomal microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N = 450 families) families ascertained from twin registries through index-cases with a lifetime history of cigarette smoking. The statistical approach used an affected-sib-pair design (at least two adult full siblings reported a history of DSM-IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores >1.5 were found on two chromosomes: 6 (FIN: LOD = 1.93 at 75 cM) and 11 at two different locations (FIN: LOD = 3.55 at 17 cM, and AUS: LOD = 1.68 with a COMB: LOD = 2.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (P = 0.013 with 1,000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: DRD4, TPH, TH, and CHRNA10. Other studies have reported that chromosome 11 may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW.

Details

Title: Genetic linkage findings for DSM-IV nicotine withdrawal in two populations
Authors: M L Pergadia (Author) - Washington University, United States
A Agrawal (Author) - Washington University, United States
A Loukola (Author) - University of Helsinki, Finland
G W Montgomery (Author) - Queensland Institute of Medical Research
U Broms (Author) - University of Helsinki, Finland
S F Saccone (Author) - Washington University, United States
J C Wang (Author) - Washington University, United States
A A Todorov (Author) - Washington University, United States
K Heikklia (Author) - Washington University, United States
Dixie J Statham (Author) - University of the Sunshine Coast - Faculty of Arts and Social Sciences
A Henders (Author) - Queensland Institute of Medical Research
M Campbell (Author) - Queensland Institute of Medical Research
J Rice (Author) - Washington University, United States
R D Todd (Author) - Washington University, United States
A C Heath (Author) - Washington University, United States
A M Goate (Author) - Washington University, United States
L Peltonen (Author) - University of Helsinki, Finland
J Kaprio (Author) - University of Helsinki, Finland
N G Martin (Author) - Queensland Institute of Medical Research
P A F Madden (Author) - Washington University, United States
Publication details: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol.150(7), pp.950-959
Publisher: John Wiley & Sons Inc.
Date published: 2009
DOI: 10.1002/ajmg.b.30924
ISSN: 1552-4841
Copyright note: Copyright © 2009 The Authors. This is the accepted version of the following article: Pergadia ML, Agrawal A, Loukola A, Montgomery GW, Broms U, Saccone SF, Wang JC, Todorov AA, Heikkilä K, Statham DJ, Henders AK, Campbell MJ, Rice JP, Todd RD, Heath AC, Goate AM, Peltonen L, Kaprio J, Martin NG, Madden PAF. 2009. Genetic Linkage Findings for DSM-IV Nicotine Withdrawal in Two Populations. Am J Med Genet Part B 150B:950-959., which has been published in final form at http://dx.doi.org/10.1002/ajmg.b.30924
Organisation Unit: School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449852102621
Output Type: Journal article

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