Genetic influences on alcohol-related hangover

Wendy S Slutske; Thomas M Piasecki; Lisa Nathanson; Dixie J Statham; Nicholas G Martin

doi:10.1111/add.12699

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Genetic influences on alcohol-related hangover

Journal article

Peer reviewed

Genetic influences on alcohol-related hangover

Wendy S Slutske, Thomas M Piasecki, Lisa Nathanson, Dixie J Statham and Nicholas G Martin

Addiction, Vol.109(12), pp.2027-2034

2014

DOI: https://doi.org/10.1111/add.12699

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Abstract

alcohol consequences

alcohol use

genetic

hangover

hangover resistance

hangover vulnerability

twins

Aims: To quantify the relative contributions of genetic and environmental factors to alcohol hangover. Design: Biometric models were used to partition the variance in hangover phenotypes. Setting: A community-based sample of Australian twins. Participants: Members of the Australian Twin Registry, Cohort II who reported consuming alcohol in the past year when surveyed in 2004-07 (n= 4496). Measurements: Telephone interviews assessed participants' frequency of drinking to intoxication and frequency of hangover the day after drinking. Analyses examined three phenotypes: hangover frequency, hangover susceptibility (i.e. residual variance in hangover frequency after accounting for intoxication frequency) and hangover resistance (a dichotomous variable defined as having been intoxicated at least once in the past year with no reported hangovers). Findings: Genetic factors accounted for 45% [95% confidence interval (CI) = 37-53%] and 40% (95% CI = 33-48%) of the variation in hangover frequency in men and women, respectively. Most of the genetic variation in hangover frequency overlapped with genetic contributions to intoxication frequency. Genetic influences accounted for 24% (95% CI = 14-35%) and 16% (95% CI = 8-25%) of the residual hangover susceptibility variance in men and women, respectively. Forty-three per cent (95% CI = 22-63%) of the variation in hangover resistance was explained by genetic influences, with no evidence for significant sex differences. There was no evidence for shared environmental influences for any of the hangover phenotypes. Conclusions: Individual differences in the propensity to experience a hangover and of being resistant to hangover at a given level of alcohol use are genetically influenced.

Details

Title: Genetic influences on alcohol-related hangover
Authors: Wendy S Slutske (Author) - University of Missouri, United States
Thomas M Piasecki (Author) - University of Missouri, United States
Lisa Nathanson (Author) - University of Missouri, United States
Dixie J Statham (Author) - University of the Sunshine Coast - Faculty of Arts and Business
Nicholas G Martin (Author) - QIMR Berghofer Medical Research Institute
Publication details: Addiction, Vol.109(12), pp.2027-2034
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2014
DOI: 10.1111/add.12699
ISSN: 0965-2140
Organisation Unit: School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449071302621
Output Type: Journal article

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Web Of Science research areas: Psychiatry; Substance Abuse

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