Journal article
Genetic association analysis of miRNA SNPs implicates MIR145 in breast cancer susceptibility
BMC Medical Genetics, Vol.16(1), 107
2015
Abstract
Background: MicroRNAs (miRNAs) are important small non-coding RNA molecules that regulate gene expression in cellular processes related to the pathogenesis of cancer. Genetic variation in miRNA genes could impact their synthesis and cellular effects and single nucleotide polymorphisms (SNPs) are one example of genetic variants studied in relation to breast cancer. Studies aimed at identifying miRNA SNPs (miR-SNPs) associated with breast malignancies could lead towards further understanding of the disease and to develop clinical applications for early diagnosis and treatment. Methods: We genotyped a panel of 24 miR-SNPs using multiplex PCR and chip-based matrix assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) analysis in two Caucasian breast cancer case control populations (Primary population: 173 cases and 187 controls and secondary population: 679 cases and 301 controls). Association to breast cancer susceptibility was determined using chi-square (X 2) and odds ratio (OR) analysis. Results: Statistical analysis showed six miR-SNPs to be non-polymorphic and twelve of our selected miR-SNPs to have no association with breast cancer risk. However, we were able to show association between rs353291 (located in MIR145) and the risk of developing breast cancer in two independent case control cohorts (p = 0.041 and p = 0.023). Conclusions: Our study is the first to report an association between a miR-SNP in MIR145 and breast cancer risk in individuals of Caucasian background. This finding requires further validation through genotyping of larger cohorts or in individuals of different ethnicities to determine the potential significance of this finding as well as studies aimed to determine functional significance. © 2015 Chacon-Cortes et al.
Details
- Title
- Genetic association analysis of miRNA SNPs implicates MIR145 in breast cancer susceptibility
- Authors
- D Chacon-Cortes (Author) - Queensland University of TechnologyR A Smith (Author) - Queensland University of TechnologyL M Haupt (Author) - Queensland University of TechnologyR A Lea (Author) - Queensland University of TechnologyPhilippa H Youl (Author) - Griffith UniversityL R Griffiths (Author) - Queensland University of Technology
- Publication details
- BMC Medical Genetics, Vol.16(1), 107; 11
- Publisher
- BioMed Central Ltd.
- Date published
- 2015
- DOI
- 10.1186/s12881-015-0248-0
- ISSN
- 1471-2350
- Copyright note
- Copyright © 2015 Chacon-Cortes et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99450925502621
- Output Type
- Journal article
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- Domestic collaboration
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- Genetics & Heredity
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