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Genetic and serum biomarker evidence for a relationship between TNFα and PTSD in Vietnam war combat veterans485.11 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Genetic and serum biomarker evidence for a relationship between TNFα and PTSD in Vietnam war combat veterans
Comprehensive Psychiatry, Vol.74, pp.125-133
2017
PMID: 28160694
Abstract
Background:
Posttraumatic stress disorder (PTSD) is associated with increased inflammation and comorbid medical conditions. However, study findings for individual inflammatory marker levels have been inconsistent. Some research suggests that resilience may play a role in decreased inflammation. A polymorphism in the promoter region of the tumor necrosis factor α gene (TNFα), TNFA −308 (rs1800629) is associated with psychiatric illness but its role in PTSD is yet to be elucidated.
Objective:
This study investigates a key inflammatory marker, TNFα, for its role in PTSD severity.
Method:
In a cohort of trauma-exposed Vietnam War veterans (n = 299; 159 cases, 140 controls) TNF α serum levels and TNFα polymorphism rs1800629 were correlated with PTSD severity and resilience scores.
Results:
The polymorphism was associated with PTSD severity (p = 0.045). There were significant group differences between cases and controls with regards to serum TNFα levels (p = 0.036). Significant correlations were found between PTSD severity and elevated TNFα levels (r = 0.153; p = 0.009), and between resilience and decreased TNFα levels at a trend level (p = 0.08) across the entire cohort. These relationships were non-significant after controlling for covariates. In the PTSD diagnostic group, a correlation of TNFα and PTSD severity was observed on a trend level (p = 0.06), the relationship between TNFα and resilience remained non-significant.
Conclusions:
To our knowledge, this is the first time rs1800629 has been investigated in PTSD contributing to a growing body of literature that identifies the GG as a risk genotype for psychiatric disorders in Caucasian cohorts. However, more research is needed to replicate our results in larger, equally well-characterized cohorts. The relationship between serum TNFα levels and PTSD severity and resilience requires further investigation.
Details
- Title
- Genetic and serum biomarker evidence for a relationship between TNFα and PTSD in Vietnam war combat veterans
- Authors
- Dagmar Bruenig (Author) - Queensland University of TechnologyDivya Mehta (Author) - Queensland University of TechnologyCharles P Morris (Author) - Queensland University of TechnologyWendy Harvey (Author) - Greenslopes Private HospitalBruce Lawford (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of Technology
- Publication details
- Comprehensive Psychiatry, Vol.74, pp.125-133
- Publisher
- Elsevier Inc.
- Date published
- 2017
- DOI
- 10.1016/j.comppsych.2017.01.015
- ISSN
- 1532-8384; 0010-440X
- PMID
- 28160694
- Copyright note
- Copyright © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550996602621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Psychiatry
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