Genetic and Proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver

Xinle Tan; Fei Gao; Hexiu Su; Yajun Gong; Mitchell A Sullivan; Jiachun Chen

doi:10.1038/srep43556

Back

Genetic and Proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver

Journal article

Open access

Peer reviewed

Genetic and Proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver

Xinle Tan, Fei Gao, Hexiu Su, Yajun Gong, Mitchell A Sullivan and Jiachun Chen

Scientific Reports, Vol.7(1), pp.1-6

2017

DOI: https://doi.org/10.1038/srep43556

PMID: 28368001

Files and links (1)

pdf

srep43556858.96 kBDownload View

Published VersionCC BY V4.0, Open Access

Abstract

DNA replication

proteomics

Snake gallbladder, a traditional Chinese medicine, has been believed in various Asian countries to improve visual acuity and alleviate rheumatism. Bile acids, a major component of the gallbladder, are toxic to the liver and kidney in humans and animals due to its detergent effects, while also exhibiting therapeutic effects due to an increase in the gallbladder contractions of muscle strips in patients with cholesterol gallstones. Secretion of bile acids in human and mammals depends on the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter encoded by ABCB11. However, the presence of BSEP in snakes has not been thoroughly explored. Here we confirm the existence of BSEP and its coding DNA sequence in snakes on both the proteomic and genetic level. This work provides information on the snake ABCB11 sequence and helps further potential genetic manipulation to affect bile salt metabolism. Our study provides the foundation for research on bile acid production from snakes by using modern genetic and proteomic methodologies.

Details

Title: Genetic and Proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver
Authors: Xinle Tan - The University of Queensland
Fei Gao - Huazhong University of Science and Technology
Hexiu Su - Huazhong University of Science and Technology
Yajun Gong - Huazhong University of Science and Technology
Mitchell A Sullivan - Hospital for Sick Children
Jiachun Chen (Corresponding Author) - Huazhong University of Science and Technology
Publication details: Scientific Reports, Vol.7(1), pp.1-6
Publisher: Nature Publishing Group
Date published: 2017
DOI: 10.1038/srep43556
ISSN: 2045-2322
PMID: 28368001
Copyright note: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Grants: Exploring the Role of Glycogen Structure in Type 2 Diabetes, 1092451, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Organisation Unit: School of Health - Biomedicine
Language: English
Record Identifier: 991035097202621
Output Type: Journal article

Metrics

14 Record Views

9 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites