Genes influence the amplitude and timing of brain hemodynamic responses

Zack Y Shan; Anna A E Vinkhuyzen; Paul M Thompson; Katie L McMahon; Gabriella A M Blokland; Greig I de Zubicaray; Vince Calhoun; Nicholas G Martin; Peter M Visscher; Margaret J Wright; David C Reutens

doi:10.1016/j.neuroimage.2015.09.016

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Genes influence the amplitude and timing of brain hemodynamic responses

Journal article

Peer reviewed

Genes influence the amplitude and timing of brain hemodynamic responses

Zack Y Shan, Anna A E Vinkhuyzen, Paul M Thompson, Katie L McMahon, Gabriella A M Blokland, Greig I de Zubicaray, Vince Calhoun, Nicholas G Martin, Peter M Visscher, Margaret J Wright, …

NeuroImage, Vol.124, pp.663-671

2016

DOI: https://doi.org/10.1016/j.neuroimage.2015.09.016

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Abstract

hemodynamic response function (HRF)

neurovascular coupling

heritability

twin study

In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology.

Details

Title: Genes influence the amplitude and timing of brain hemodynamic responses
Authors: Zack Y Shan (Author) - University of Queensland
Anna A E Vinkhuyzen (Author) - University of Queensland
Paul M Thompson (Author) - University of Southern California, United States
Katie L McMahon (Author) - University of Queensland
Gabriella A M Blokland (Author) - University of Queensland
Greig I de Zubicaray (Author) - University of Queensland
Vince Calhoun (Author) - University of New Mexico, United States
Nicholas G Martin (Author) - QIMR Berghofer Medical Research Institute
Peter M Visscher (Author) - University of Queensland
Margaret J Wright (Author) - QIMR Berghofer Medical Research Institute
David C Reutens (Author) - University of Queensland
Publication details: NeuroImage, Vol.124, pp.663-671
Publisher: Elsevier BV
Date published: 2016
DOI: 10.1016/j.neuroimage.2015.09.016
ISSN: 1053-8119
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451317802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neuroimaging; Neurosciences; Radiology, Nuclear Medicine & Medical Imaging

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