Journal article
Gene expression in response to exercise in patients with chronic fatigue syndrome: A pilot study
Frontiers in Physiology, Vol.7, pp.1-7
2016
PMID: 27713703
Abstract
Chronic fatigue syndrome (CFS) is a debilitating disorder of unknown pathogenesis, characterized by fatigue, which is exacerbated after minimal exercise. We examined the effect of a single bout of aerobic exercise on leucocyte mRNA expression of genes putatively linked to exaggerated afferent signaling as an under-pinning of the fatigue state. A carefully-characterized sample of patients with CFS (N = 10) and healthy matched control participants (N = 12) were included. Participant ratings of fatigue and other symptoms, as well as blood samples, were obtained at baseline, and five other time-points up to 72 h after 25 min of moderate-intensity cycling exercise. Leucocyte mRNA of 19 metabolite-sensing, adrenergic, immune, and neurotransmission genes was examined using quantitative polymerase chain reaction. Patients with CFS reported substantial fatigue, functional impairment, and poor sleep at baseline (all p < 0.02), and exercise immediately induced worsened patients' fatigue (effect size, ES = 1.17). There were no significant changes in gene expression after exercise and patients did not differ from control participants at any time point. Higher levels of expression of ficolin (FCN1) and a purinergic receptor (P2RX4) in patients with CFS were found when all time points were combined. Patients with CFS did not show significant exercise-induced changes in leucocyte mRNA of 19 metabolite-sensing, adrenergic, immune and neurotransmission genes despite a prominent exacerbation of fatigue.
Details
- Title
- Gene expression in response to exercise in patients with chronic fatigue syndrome: A pilot study
- Authors
- Andrew Keech (Corresponding Author) - UNSW SydneyUte Vollmer-Conna (Author) - UNSW SydneyBenjamin K. Barry (Author) - UNSW SydneyAndrew R. Lloyd (Author) - UNSW Sydney
- Publication details
- Frontiers in Physiology, Vol.7, pp.1-7
- Publisher
- Frontiers Research Foundation
- Date published
- 2016
- DOI
- 10.3389/fphys.2016.00421
- ISSN
- 1664-042X
- PMID
- 27713703
- Copyright note
- Copyright © 2016 Keech, Vollmer-Conna, Barry and Lloyd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Grant note
- AK was supported by funding from the Judith Jane Mason and Harold Stannett Williams Memorial Foundation (RG114143).
- Organisation Unit
- School of Health - Sports & Exercise Science
- Language
- English
- Record Identifier
- 991225012902621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Physiology