Gene Silencing in Crustaceans: From Basic Research to Biotechnologies

Amir Sagi; Rivka Manor; Tomer Ventura

doi:10.3390/genes4040620

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Gene Silencing in Crustaceans: From Basic Research to Biotechnologies

Journal article

Open access

Peer reviewed

Gene Silencing in Crustaceans: From Basic Research to Biotechnologies

Amir Sagi, Rivka Manor and Tomer Ventura

Genes, Vol.4(4), pp.620-645

2013

DOI: https://doi.org/10.3390/genes4040620

PMCID: PMC3927571

PMID: 24705266

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Abstract

crustacean

gene function

RNA interference

humoral defense mechanisms

androgenic gland

insulin-like peptide

biotechnology

Gene silencing through RNA interference (RNAi) is gaining momentum for crustaceans, both in basic research and for commercial development. RNAi has proven instrumental in a growing number of crustacean species, revealing the functionality of novel crustacean genes essential among others to development, growth, metabolism and reproduction. Extensive studies have also been done on silencing of viral transcripts in crustaceans, contributing to the understanding of the defense mechanisms of crustaceans and strategies employed by viruses to overcome these. The first practical use of gene silencing in aquaculture industry has been recently achieved, through manipulation of a crustacean insulin-like androgenic gland hormone. This review summarizes the advancements in the use of RNAi in crustaceans, and assesses the advantages of this method, as well as the current hurdles that hinder its large-scale practice.

Details

Title: Gene Silencing in Crustaceans: From Basic Research to Biotechnologies
Authors: Amir Sagi (Author) - Ben-Gurion University, Israel
Rivka Manor (Author) - Ben-Gurion University, Israel
Tomer Ventura (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Genes, Vol.4(4), pp.620-645
Publisher: MDPI AG
Date published: 2013
DOI: 10.3390/genes4040620
ISSN: 2073-4425
PMID: 24705266; PMC3927571
Copyright note: Copyright © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450074702621
Output Type: Journal article

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