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Ganglion cell-inner plexiform layer measurements derived from widefield compared to montaged 9-field optical coherence tomography2.21 MB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Ganglion cell-inner plexiform layer measurements derived from widefield compared to montaged 9-field optical coherence tomography
Clinical and Experimental Optometry, Vol.105(8), pp.822-830
2022
PMID: 34791988
Abstract
Clinical relevance:
With equivalent inner retinal thickness measurements compared to a more conventional composite optical coherence tomography (OCT) protocol, Widefield optical coherence tomography (WF-OCT) is a clinically viable, time-saving option facilitating detection of ocular pathologies within the central 55° of the retina.
Purpose:
To compare ganglion cell-inner plexiform layer (GCIPL) thicknesses obtained using a single WF-OCT scan and standard composite OCT scans acquired in 9 fields of gaze (9F-OCT).
Methods:
Thirteen healthy participants underwent WF-OCT and 9F-OCT using the Spectralis OCT. The GCIPL was automatically segmented with a manual review for 9F-OCT and was manually segmented for WF-OCT. After registration, differences in GCIPL thicknesses were compared using 95% confidence intervals computed from one-sample t-tests and Bland-Altman analyses. Location-specific differences in B-scan tilt were analysed using Spearman correlations and linear regression models. To determine whether B-scan tilt influences GCIPL measurements, regression models of tilt versus differences between perpendicular and axial GCIPL thickness were applied.
Results:
While scattered locations demonstrated significant GCIPL thickness differences between WF-OCT and 9F-OCT, most differences did not exceed the axial pixel resolution of the instrument of 3.87 µm. Bland-Altman analyses indicated no notable bias using WF-OCT. Moderate correlations indicating significant location-specific differences in B-scan tilt were observed for temporal, central and inferior B-scans (r = −0.62 to 0.72), with linear regression models predicting a maximum difference in the tilt of 4.65°. The quadratic regression model indicated that at tilts greater than 27.3°, perpendicular GCIPL measurements become increasingly thin relative to axial measurements.
Conclusions:
GCIPL thicknesses and B-scan tilts from WF-OCT are comparable to 9F-OCT, indicating that WF-OCT can be applied clinically to obtain valid inner retinal OCT measurements over 55° of the central retina with relative ease. However, for peripheral locations, B-scan tilt may need to be considered when measuring GCIPL thicknesses.
Details
- Title
- Ganglion cell-inner plexiform layer measurements derived from widefield compared to montaged 9-field optical coherence tomography
- Authors
- Janelle Tong (Author) - UNSW SydneyNayuta Yoshioka (Author) - UNSW SydneyDavid Alonso-Caneiro (Author) - Queensland University of TechnologyBarbara Zangerl (Corresponding Author) - UNSW Sydney
- Publication details
- Clinical and Experimental Optometry, Vol.105(8), pp.822-830
- Publisher
- Taylor & Francis
- Date published
- 2022
- DOI
- 10.1080/08164622.2021.1993058
- ISSN
- 1444-0938; 0816-4622
- PMID
- 34791988
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99972397502621
- Output Type
- Journal article
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