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Published VersionCC BY V4.0, Open Access
Journal article
GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential
International Journal of Biological Sciences, Vol.17(8), pp.2050-2068
2021
Abstract
Type 2 diabetes mellitus (T2DM) is closely associated with cardiovascular diseases (CVD), including atherosclerosis, hypertension and heart failure. Some anti-diabetic medications are linked with an increased risk of weight gain or hypoglycemia which may reduce the efficacy of the intended anti-hyperglycemic effects of these therapies. The recently developed receptor agonists for glucagon-like peptide-1 (GLP-1RAs), stimulate insulin secretion and reduce glycated hemoglobin levels without having side effects such as weight gain and hypoglycemia. In addition, GLP1-RAs demonstrate numerous cardiovascular protective effects in subjects with or without diabetes. There have been several cardiovascular outcomes trials (CVOTs) involving GLP-1RAs, which have supported the overall cardiovascular benefits of these drugs. GLP1-RAs lower plasma lipid levels and lower blood pressure (BP), both of which contribute to a reduction of atherosclerosis and reduced CVD. GLP-1R is expressed in multiple cardiovascular cell types such as monocyte/macrophages, smooth muscle cells, endothelial cells, and cardiomyocytes. Recent studies have indicated that the protective properties against endothelial dysfunction, anti-inflammatory effects on macrophages and the anti-proliferative action on smooth muscle cells may contribute to atheroprotection through GLP-1R signaling. In the present review, we describe the cardiovascular effects and underlying molecular mechanisms of action of GLP-1RAs in CVOTs, animal models and cultured cells, and address how these findings have transformed our understanding of the pharmacotherapy of T2DM and the prevention of CVD.
Details
- Title
- GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential
- Authors
- Xiaoxuan Ma (Author) - University of Science and Technology of ChinaZhenghong Lui (Author) - University of Science and Technology of ChinaIqra Ilyas (Author) - University of Science and Technology of ChinaPeter James Little (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyDanielle Kamato (Author) - The University of QueenslandAmirhossein Sahebkar (Author)Zhengfang Chen (Author) - Soochow UniversitySihui Luo (Author) - University of Science and Technology of ChinaXueying Zheng (Author) - Changshu No.1 People's HospitalJianping Weng (Author) - University of Science and Technology of ChinaSuowen Xu (Author) - University of Science and Technology of China
- Publication details
- International Journal of Biological Sciences, Vol.17(8), pp.2050-2068
- Publisher
- Ivyspring International Publisher
- Date published
- 2021
- DOI
- 10.7150/ijbs.59965
- ISSN
- 1449-2288
- Copyright note
- © The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See: http://ivyspring.com/terms for full terms and conditions.
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99534606202621
- Output Type
- Journal article
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