GABAA receptor β3 subunit gene and psychiatric morbidity in a post-traumatic stress disorder population

Jamie Feusner; Terry L Ritchie; Bruce R Lawford; Ross Young; Burnett Kann; Ernest P Noble

doi:10.1016/S0165-1781(01)00296-7

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GABAA receptor β3 subunit gene and psychiatric morbidity in a post-traumatic stress disorder population

Journal article

Peer reviewed

GABAA receptor β3 subunit gene and psychiatric morbidity in a post-traumatic stress disorder population

Jamie Feusner, Terry L Ritchie, Bruce R Lawford, Ross Young, Burnett Kann and Ernest P Noble

Psychiatry Research, Vol.104(2), pp.109-117

2001

DOI: https://doi.org/10.1016/S0165-1781(01)00296-7

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Abstract

Post-traumatic stress disorder

General Health Questionnaire

Association analysis

Anxiety

Depression

Heterosis

GABAergic systems have been implicated in the pathogenesis of anxiety, depression and insomnia. These Ž. symptoms are part of the core and comorbid psychiatric disturbances in post-traumatic stress disorder PTSD. In a sample of Caucasian male PTSD patients, dinucleotide repeat polymorphisms of the GABA receptor 3 subunit A Ž. gene were compared to scores on the General Health Questionnaire-28 GHQ. As the major allele at this gene Ž. locus GABRB3 was G1, the alleles were divided into G1 and non-G1 groups. On the total score of the GHQ, which comprises the somatic symptoms, anxietyrinsomnia, social dysfunction and depression subscales, patients with the Ž. G1 non-G1 genotype had a significantly higher score when compared to either the G1G1 genotype s 0.01 or the Ž. non-G1 non-G1 genotype s 0.05. No significant difference was found between the G1G1 and non-G1 non-G1 genotypes. When the G1 non-G1 heterozygotes were compared to the combined G1G1 and non-G1 non-G1 Ž. homozygotes, a significantly higher total GHQ score was found in the heterozygotes Ps 0.002. These observations suggest a heterosis effect. Further analysis of GHQ subscale scores showed that heterozygotes compared to the Ž. Ž. combined homozygotes had higher scores on the somatic symptoms Ps 0.006 , anxietyrinsomnia Ps 0.003 , social Ž. Ž. dysfunction Ps 0.054 and depression Ps 0.004 subscales. In conclusion, the present study indicates that in a Ž. population of PTSD patients, heterozygosity of the GABRB3 major G1 allele confers higher levels of somatic symptoms, anxietyrinsomnia, social dysfunction and depression than found in homozygosity.

Details

Title: GABAA receptor β3 subunit gene and psychiatric morbidity in a post-traumatic stress disorder population
Authors: Jamie Feusner (Author) - UCLA Neuropsychiatric Institute
Terry L Ritchie (Author) - UCLA Neuropsychiatric Institute
Bruce R Lawford (Author) - Greenslopes Private Hospital
Ross Young (Author) - University of Queensland
Burnett Kann (Author) - Greenslopes Private Hospital
Ernest P Noble (Author) - UCLA Neuropsychiatric Institute
Publication details: Psychiatry Research, Vol.104(2), pp.109-117
Publisher: Elsevier Ireland Ltd.
DOI: 10.1016/S0165-1781(01)00296-7
ISSN: 1872-7123
Organisation Unit: University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
Language: English
Record Identifier: 99550996802621
Output Type: Journal article

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Web Of Science research areas: Psychiatry

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