Journal article
Functional connectivity of brain associated with passive range of motion exercise: Proprioceptive input promoting motor activation?
NeuroImage, Vol.202, pp.1-10
2019
PMID: 31325644
Abstract
Soft robotics have come to the forefront of devices available for rehabilitation following stroke; however, objective evaluation of the specific brain changes following rehabilitation with these devices is lacking. In this study, we utilized functional Magnetic Resonance Imaging (fMRI) and dynamic causal modeling (DCM) to characterize the activation of brain areas with a MRI compatible glove actuator compared to the conventional manual therapy. Thirteen healthy volunteers engaged in a motor-visual fMRI task under four different conditions namely active movement, manual passive movement, passive movement using a glove actuator, and crude tactile stimulation. Brain activity following each task clearly identified the somatosensory motor area (SMA) as a major hub orchestrating activity between the primary motor (M1) and sensory (S1) cortex.
During the glove-induced passive movement, activity in the motor-somatosensory areas was reduced, but there were significant increases in motor cortical activity compared to manual passive movement. We estimated the modulatory signaling from within a defined sensorimotor network (SMA, M1, and S1), through DCM and highlighted a dual-gating of sensorimotor inputs to the SMA. Proprioceptive signaling from S1 to the SMA reflected positive coupling for the manually assisted condition, while M1 activity was positively coupled to the SMA during the glove condition. Importantly, both the S1 and M1 were shown to influence each other’s connections with the SMA, with inhibitory nonlinear modulation by the M1 on the S1-SMA connection, and similarly S1 gated the M1-SMA connection. The work is one of the first to have applied effective connectivity to examine sensorimotor activity ensued by manual or robotic passive range of motion exercise, crude tactile stimulation, and voluntary movements to provide a basis for the mechanism by which soft actuators can alter brain activity.
•Proprioceptive drive elicited by passive range of motion exercise may activate supplementary and primary motor cortex.•Somatosensory cortex gates interaction between supplementary and primary motor cortex reciprocating signals to the former.•Primary motor or somatosensory cortex initiates feedback to supplementary motor area for proprioceptive motor integration.•This study implies the benefit of passive range of motion exercise to promote motor functional activity of the brain.
Details
- Title
- Functional connectivity of brain associated with passive range of motion exercise: Proprioceptive input promoting motor activation?
- Authors
- Fatima A Nasrallah (Author) - University of QueenslandAbdalla Z Mohamed (Author) - University of QueenslandMegan E J Campbell (Author) - University of QueenslandHong Kai Yap (Author) - Singapore Institute of Neurotechnology and Advanced Robotics Center, SingaporeChen-Hua Yeow (Author) - National University of SingaporeJeong Hoon Lim (Author) - National University of Singapore
- Publication details
- NeuroImage, Vol.202, pp.1-10
- Publisher
- Elsevier BV
- DOI
- 10.1016/j.neuroimage.2019.116023
- ISSN
- 1095-9572
- PMID
- 31325644
- Organisation Unit
- Thompson Institute; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99522404502621
- Output Type
- Journal article
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- Web Of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging
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