Fronto-temporal functional disconnection precedes hippocampal atrophy in clinically confirmed multi-domain amnestic Mild Cognitive Impairment

Kathryn Broadhouse; Natalie Winks; Mathew Summers

doi:10.17179/excli2021-4191

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Fronto-temporal functional disconnection precedes hippocampal atrophy in clinically confirmed multi-domain amnestic Mild Cognitive Impairment

Journal article

Open access

Peer reviewed

Fronto-temporal functional disconnection precedes hippocampal atrophy in clinically confirmed multi-domain amnestic Mild Cognitive Impairment

Kathryn Broadhouse, Natalie Winks and Mathew Summers

EXCLI Journal, Vol.20, pp.1458-1473

2021

DOI: https://doi.org/10.17179/excli2021-4191

PMCID: PMC8564906

PMID: 34737688

Appears in Thompson Institute Research Collection

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Abstract

Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)

Clinical Health (Organs, Diseases and Abnormal Conditions)

Mild cognitive impairment

functional magnetic resonance imaging

cognitive function

Alz- heimer's Dementia

cognitive decline

Neuroimaging

Thompson Institute Special Collection

UniSC Diversity Area - Disability and Inclusion

UniSC Diversity Area - Life Stages

Mild Cognitive Impairment (MCI) is fraught with high false positive diagnostic errors. The high rate of false positive diagnosis hampers attempts to identify reliable and valid biomarkers for MCI. Recent research suggests that aberrant functional neurocircuitries emerge prior to significant cognitive deficits. The aim of the present study was to examine this in clinically confirmed multi-domain amnestic-MCI (mdaMCI) using an established, multi-time point, methodology for minimizing false positive diagnosis. Structural and resting-state functional MRI data were acquired in healthy controls (HC, n=24), clinically-confirmed multi-domain amnestic-MCI (mdaMCI, n=14) and mild Alzheimer's Dementia (mAD, n=6). Group differences in cortical thickness, hippocampal volume and functional connectivity were investigated. Hippocampal subvolumes differentiated mAD from HC and mdaMCI. Functional decoupling of fronto-temporal networks implicated in memory and executive function differentiated HC and mdaMCI. Decreased functional connectivity in these networks was associated with poorer cognitive performance scores. Preliminary findings suggest the large-scale decoupling of fronto-temporal networks associated with cognitive decline precedes measurable structural neurodegeneration in clinically confirmed MCI and may represent a potential biomarker for disease progression.

Details

Title: Fronto-temporal functional disconnection precedes hippocampal atrophy in clinically confirmed multi-domain amnestic Mild Cognitive Impairment
Authors: Kathryn Broadhouse (Author) - University of the Sunshine Coast, Queensland, School of Science and Engineering - Legacy
Natalie Winks (Author) - Sunshine Coast Hospital and Health Service
Mathew Summers (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Publication details: EXCLI Journal, Vol.20, pp.1458-1473
Publisher: EXCLI Journal
Date published: 2021
DOI: 10.17179/excli2021-4191
ISSN: 1611-2156
PMID: 34737688; PMC8564906
Copyright note: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Health; School of Health - Nursing; University of the Sunshine Coast, Queensland; Thompson Institute; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99571508902621
Output Type: Journal article

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