Fronto-striatal correlates of impaired implicit sequence learning in major depression: An fMRI study

S L Naismith; Jim Lagopoulos; P B Ward; C G Davey; C Little; I B Hickie

doi:10.1016/j.jad.2010.02.114

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Fronto-striatal correlates of impaired implicit sequence learning in major depression: An fMRI study

Journal article

Peer reviewed

Fronto-striatal correlates of impaired implicit sequence learning in major depression: An fMRI study

S L Naismith, Jim Lagopoulos, P B Ward, C G Davey, C Little and I B Hickie

Journal of Affective Disorders, Vol.125(1-3), pp.256-261

2010

DOI: https://doi.org/10.1016/j.jad.2010.02.114

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Abstract

depression

implicit learning

motor sequencing

striatum

fMRI

cognition

Background: Neural network models of major depression (MD) suggest that the striatum is involved in the pathophysiology and is linked to key cognitive and clinical features. However, functional imaging studies have largely assessed the prefrontal cortex and have utilised emotional paradigms. This study sought to probe the integrity of fronto-striatal circuits using functional magnetic resonance imaging (fMRI) in conjunction with a theoretically-driven motor sequencing implicit learning (IL) task. Methods: Nineteen patients with MD (mean age = 56.1 years, sd = 9.8) and 20 control participants (mean age = 50.6 years, sd = 11.9) participated. A blocked fMRI paradigm was used in association with a motor sequencing task which included an IL and random sequence (baseline) condition. Although the study was hypothesis driven, within and between groups whole-brain analysis was used to examine fMRI patterns in the IL compared to BL condition. Results: While both groups activated the striatum, there was no significant difference between patients and controls in striatal activation. Instead, control subjects showed significantly greater activity in the middle frontal gyrus whereas the patients exhibited greater activity in the superior temporal gyrus and cerebellum. Limitations: Most patients were receiving antidepressant medication when assessed. An event-related fMRI design would have enabled more fine-grained temporal analysis of IL related activation. Conclusions: IL deficits in MD are not due primarily to striatal dysfunction. IL performance may depend on more specific sub-components of the striatum or a more distributed neural network involving frontal, temporal and cerebellar regions. © 2010 Elsevier B.V. All rights reserved.

Details

Title: Fronto-striatal correlates of impaired implicit sequence learning in major depression: An fMRI study
Authors: S L Naismith (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
P B Ward (Author) - University of New South Wales
C G Davey (Author) - University of Melbourne
C Little (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Publication details: Journal of Affective Disorders, Vol.125(1-3), pp.256-261
Publisher: Elsevier BV
Date published: 2010
DOI: 10.1016/j.jad.2010.02.114
ISSN: 0165-0327
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449197502621
Output Type: Journal article

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Web Of Science research areas: Clinical Neurology; Psychiatry

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