Frontal and subcortical grey matter reductions in PTSD

Daniel C M O'Doherty; Ashleigh Tickell; Will Ryder; Charles Chan; Daniel F Hermens; Maxwell Bennett; Jim Lagopoulos

doi:10.1016/j.pscychresns.2017.05.008

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Frontal and subcortical grey matter reductions in PTSD

Journal article

Open access

Peer reviewed

Frontal and subcortical grey matter reductions in PTSD

Daniel C M O'Doherty, Ashleigh Tickell, Will Ryder, Charles Chan, Daniel F Hermens, Maxwell Bennett and Jim Lagopoulos

Psychiatry Research: Neuroimaging, Vol.266, pp.1-19

2017

DOI: https://doi.org/10.1016/j.pscychresns.2017.05.008

PMID: 28549317

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

VBM

posttraumatic stress disorder

MRI

UniSC Diversity Area - Disability and Inclusion

Post-traumatic stress disorder (PTSD) is characterised by a range of debilitating psychological, physical and cognitive symptoms. PTSD has been associated with grey matter atrophy in limbic and frontal cortical brain regions. However, previous studies have reported heterogeneous findings, with grey matter changes observed beyond limbic/frontal areas. Seventy-five adults were recruited from the community, 25 diagnosed with PTSD along with 25 healthy and 25 trauma exposed age and gender matched controls. Participants underwent clinical assessment and magnetic resonance imaging. The data-analyses method Voxel Based Morphometry (VBM) was used to estimate cortical grey matter volumes. When compared to both healthy and trauma exposed controls, PTSD subjects demonstrated decreased grey matter volumes within subcortical brain regions-including the hippocampus and amygdala-along with reductions in the anterior cingulate cortex, frontal medial cortex, middle frontal gyrus, superior frontal gyrus, paracingulate gyrus, and precuneus cortex. Significant negative correlations were found between total CAPS lifetime clinical scores/sub-scores and GM volume of both the PTSD and TC groups. GM volumes of the left rACC and right amygdala showed a significant negative correlation within PTSD diagnosed subjects.

Details

Title: Frontal and subcortical grey matter reductions in PTSD
Authors: Daniel C M O'Doherty (Author) - The University of Sydney
Ashleigh Tickell (Author) - The University of Sydney
Will Ryder (Author) - The University of Sydney
Charles Chan (Author) - The University of Sydney
Daniel F Hermens (Author) - The University of Sydney
Maxwell Bennett (Author) - The University of Sydney
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Publication details: Psychiatry Research: Neuroimaging, Vol.266, pp.1-19
Publisher: Elsevier Ireland Ltd.
Date published: 2017
DOI: 10.1016/j.pscychresns.2017.05.008
ISSN: 0925-4927
PMID: 28549317
Copyright note: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Organisation Unit: Thompson Institute
Language: English
Record Identifier: 99451144102621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology; Neuroimaging; Psychiatry

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