Frequent tRNA gene translocation towards the boundaries with control regions contributes to the highly dynamic mitochondrial genome organization of the parasitic lice of mammals

Wen-Ge Dong; Yalun Dong; Xian-Guo Guo; Renfu Shao

doi:10.1186/s12864-021-07859-w

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Frequent tRNA gene translocation towards the boundaries with control regions contributes to the highly dynamic mitochondrial genome organization of the parasitic lice of mammals

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Frequent tRNA gene translocation towards the boundaries with control regions contributes to the highly dynamic mitochondrial genome organization of the parasitic lice of mammals

Wen-Ge Dong, Yalun Dong, Xian-Guo Guo and Renfu Shao

BMC Genomics, Vol.22, pp.1-16

2021

DOI: https://doi.org/10.1186/s12864-021-07859-w

PMCID: PMC8344215

PMID: 34362306

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Abstract

Genome fragmentation

Mitochondrial karyotype

Parasitic lice

tRNA translocation

Background: The typical single-chromosome mitochondrial (mt) genome of animals has fragmented into multiple minichromosomes in the lineage Mitodivisia, which contains most of the parasitic lice of eutherian mammals. These parasitic lice differ from each other even among congeneric species in mt karyotype, i.e. the number of minichromosomes, and the gene content and gene order in each minichromosome, which is in stark contrast to the extremely conserved single-chromosome mt genomes across most animal lineages. How fragmented mt genomes evolved is still poorly understood. We use Polyplax sucking lice as a model to investigate how tRNA gene translocation shapes the dynamic mt karyotypes. Results: We sequenced the full mt genome of the Asian grey shrew louse, Polyplax reclinata. We then inferred the ancestral mt karyotype for Polyplax lice and compared it with the mt karyotypes of the three Polyplax species sequenced to date. We found that tRNA genes were entirely responsible for mt karyotype variation among these three species of Polyplax lice. Furthermore, tRNA gene translocation observed in Polyplax lice was only between different types of minichromosomes and towards the boundaries with the control region. A similar pattern of tRNA gene translocation can also been seen in other sucking lice with fragmented mt genomes. Conclusions: We conclude that inter-minichromosomal tRNA gene translocation orientated towards the boundaries with the control region is a major contributing factor to the highly dynamic mitochondrial genome organization in the parasitic lice of mammals.

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Title: Frequent tRNA gene translocation towards the boundaries with control regions contributes to the highly dynamic mitochondrial genome organization of the parasitic lice of mammals
Authors: Wen-Ge Dong (Author) - Dali University
Yalun Dong (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Xian-Guo Guo (Author) - Dali University
Renfu Shao (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Publication details: BMC Genomics, Vol.22, pp.1-16
Publisher: BioMed Central Ltd.
Date published: 2021
DOI: 10.1186/s12864-021-07859-w
ISSN: 1471-2164
PMID: 34362306; PMC8344215
Copyright note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Organisation Unit: University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99564006702621
Output Type: Journal article

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Web Of Science research areas: Biotechnology & Applied Microbiology; Genetics & Heredity

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