Fibrillin-rich microfibrils of the extracellular matrix: Ultrastructure and assembly

M J Sherratt; Tim J Wess; Clair Baldock; J Ashworth; P P Purslow; C A Shuttleworth; C M Kielty

doi:10.1016/S0968-4328(99)00082-7

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Fibrillin-rich microfibrils of the extracellular matrix: Ultrastructure and assembly

Journal article

Peer reviewed

Fibrillin-rich microfibrils of the extracellular matrix: Ultrastructure and assembly

M J Sherratt, Tim J Wess, Clair Baldock, J Ashworth, P P Purslow, C A Shuttleworth and C M Kielty

Micron, Vol.32(2), pp.185-200

2001

DOI: https://doi.org/10.1016/S0968-4328(99)00082-7

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Abstract

fibrillin

microfibrils

ultrastructure

supramolecular organisation

scanning transmission electron microscopy

transmission electron microscopy

environmental scanning electron microscopy

atomic force microscopy

Fibrillin-rich microfibrils are a unique class of extensible connective tissue macromolecules. Their critical contribution to the establishment and maintenance of diverse extracellular matrices was underlined by the linkage of their principal structural component fibrillin to Marfan syndrome, a heritable connective tissue disorder with pleiotropic manifestations. Microscopy and preparative techniques have contributed substantially to the understanding of microfibril structure and function. The supramolecular organisation of microfibrillar assemblies in tissues has been examined by tissue sectioning and X-ray diffraction methods. Published findings are discussed and new information reported on the organisation of microfibrils in the ciliary zonular fibrils by environmental scanning electron microscopy. This review summarises microscopy and X-ray diffraction studies that are informing current understanding of the ultrastructure of fibrillin-rich microfibrils. (C) 2000 Published by Elsevier Science Ltd.

Details

Title: Fibrillin-rich microfibrils of the extracellular matrix: Ultrastructure and assembly
Authors: M J Sherratt (Author) - University of Manchester, United Kingdom
Tim J Wess (Author) - University of Stirling, United Kingdom
Clair Baldock (Author) - University of Manchester, United Kingdom
J Ashworth (Author) - University of Manchester, United Kingdom
P P Purslow (Author) - Royal Veterinary and Agricultural University, Denmark
C A Shuttleworth (Author) - University of Manchester, United Kingdom
C M Kielty (Author) - University of Manchester, United Kingdom
Publication details: Micron, Vol.32(2), pp.185-200
Publisher: Pergamon
Date published: 2001
DOI: 10.1016/S0968-4328(99)00082-7
ISSN: 0968-4328
Organisation Unit: Office of the Deputy Vice-Chancellor (Academic); University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450615002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Microscopy

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