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Journal article
Females Display Lower Risk of Myocardial Infarction From Higher Estimated Cardiorespiratory Fitness Than Males: The Tromsø Study 1994-2014
Mayo Clinic Proceedings. Innovations, Quality and Outcomes, Vol.8(1), pp.P62-P73
2024
PMID: 38268988
Abstract
Objective
To examine the dose-response association between estimated cardiorespiratory fitness (eCRF) and risk of myocardial infarction (MI).
Patients and Methods
Adults who attended Tromsø Study surveys 4-6 (Janurary 1,1994-December 20, 2008) with no previous cardiovascular disease were followed up through December 31, 2014 for incident MI. Associations were examined using restricted cubic splines Fine and Gray regressions, adjusted for education, smoking, alcohol, diet, sex, adiposity, physical activity, study survey, and age (timescale) in the total cohort and subsamples with hyperlipidemia (n=2956), hypertension (n=8290), obesity (n=5784), metabolic syndrome (n=1410), smokers (n=3823), and poor diet (n=3463) and in those who were physically inactive (n=6255).
Results
Of 14,285 participants (mean age ± SD, 53.7±11.4 years), 979 (6.9%) experienced MI during follow-up (median, 7.2 years; 25th-75th, 5.3-14.6 years). Females with median eCRF (32 mL/kg/min) had 43% lower MI risk (subdistributed hazard ratio [SHR], 0.57; 95% CI, 0.48-0.68) than those at the 10th percentile (25 mL/kg/min) as reference. The lowest MI risk was observed at 47 mL/kg/min (SHR, 0.02; 95% CI, 0.01-0.11). Males had 26% lower MI risk at median eCRF (40 mL/kg/min; SHR, 0.74; 95% CI, 0.63-0.86) than those at the 10th percentile (32 mL/kg/min), and the lowest risk was 69% (SHR, 0.31; 95% CI, 0.14-0.71) at 60 mL/kg/min. The associations were similar in subsamples with cardiovascular disease risk factors.
Conclusion
Higher eCRF associated with lower MI risk in females and males, but associations were more pronounced among females than those in males. This suggest eCRF as a vital estimate to implement in medical care to identify individuals at high risk of future MI, especially for females.
Details
- Title
- Females Display Lower Risk of Myocardial Infarction From Higher Estimated Cardiorespiratory Fitness Than Males: The Tromsø Study 1994-2014
- Authors
- Edvard H. Sagelv (Corresponding Author) - UiT The Arctic University of NorwayAndrea Casolo - University of PaduaAnne Elise Eggen - UiT The Arctic University of NorwayKim Arne Heitmann - UiT The Arctic University of NorwayKristoffer R. Johansen - UiT The Arctic University of NorwayMaja-Lisa Løchen - UiT The Arctic University of NorwayEllisiv B. Mathiesen - University Hospital of North NorwayBente Morseth - UiT The Arctic University of NorwayInger Njølstad - UiT The Arctic University of NorwayJohn O Osborne - UiT The Arctic University of NorwayKarianne Hagerupsen - UiT The Arctic University of NorwaySigurd Pedersen - UiT The Arctic University of NorwayTom Wilsgaard - UiT The Arctic University of Norway
- Publication details
- Mayo Clinic Proceedings. Innovations, Quality and Outcomes, Vol.8(1), pp.P62-P73
- Publisher
- Elsevier Inc.
- Date published
- 2024
- DOI
- 10.1016/j.mayocpiqo.2023.12.007
- ISSN
- 2542-4548
- PMID
- 38268988
- Copyright note
- © 2023 The Authors. Published by Elsevier Inc on behalf of Mayo Foundation for Medical Education and Research. User License: Creative Commons Attribution (CC BY 4.0)
- Grant note
- This work was funded by High North Population studies, an internally funded research project at UiT The Arctic University of Norway to E.H.S. (no grant number). The remaining authors are funded through their respective positions/tenures.
- Organisation Unit
- School of Health
- Language
- English
- Record Identifier
- 991110345102621
- Output Type
- Journal article
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