Journal article
Feasibility and initial validation of 'HD-Mobile', a smartphone application for remote self-administration of performance-based cognitive measures in Huntington's disease
Journal of Neurology, Vol.268(2), pp.590-601
2021
PMID: 32880724
Abstract
Objective Smartphone-based cognitive assessment measures allow efficient, rapid, and convenient collection of cognitive datasets. Establishment of feasibility and validity is essential for the widespread use of this approach. We describe a novel smartphone application (HD-Mobile) that includes three performance-based cognitive tasks with four key outcome measures, for use with Huntington's disease (HD) samples. We describe known groups and concurrent validity, test-retest reliability, sensitivity, and feasibility properties of the tasks. Methods Forty-two HD CAG-expanded participants (20 manifest, 22 premanifest) and 28 healthy controls completed HD-Mobile cognitive tasks three times across an 8-day period, on days 1, 4, and 8. A subsample of participants had pen-and-paper cognitive task data available from their most recent assessment from their participation in a separate observational longitudinal study, Enroll-HD. Results Manifest-HD participants performed worse than healthy controls for three of four HD-Mobile cognitive measures, and worse than premanifest-HD participants for two of four measures. We found robust test-retest reliability for manifest-HD participants (ICC = 0.71-0.96) and with some exceptions, in premanifest-HD (ICC = 0.52-0.96) and healthy controls (0.54-0.96). Correlations between HD-Mobile and selected Enroll-HD cognitive tasks were mostly medium to strong (r = 0.36-0.68) as were correlations between HD-Mobile cognitive tasks and measures of expected disease progression and motor symptoms for the HD CAG-expanded participants (r = - 0.34 to - 0.54). Conclusions Results indicated robust known-groups, test-retest, concurrent validity, and sensitivity of HD-Mobile cognitive tasks. The study demonstrates the feasibility and utility of HD-Mobile for conducting convenient, frequent, and potentially ongoing assessment of HD samples without the need for in-person assessment.
Details
- Title
- Feasibility and initial validation of 'HD-Mobile', a smartphone application for remote self-administration of performance-based cognitive measures in Huntington's disease
- Authors
- Brendan McLaren (Author) - Monash UniversitySophie C. Andrews (Author) - Monash UniversityYifat Glikmann-Johnston (Author) - Monash UniversityEmily-Clare Mercieca (Author) - Monash UniversityNicholas W. G. Murray (Author) - Westmead HospitalClement Loy (Author) - University of SydneyMark A. Bellgrove (Author) - Monash UniversityJulie C. Stout (Corresponding Author) - Monash University
- Publication details
- Journal of Neurology, Vol.268(2), pp.590-601
- Publisher
- Springer Medizin
- DOI
- 10.1007/s00415-020-10169-y
- ISSN
- 1432-1459
- PMID
- 32880724
- Organisation Unit
- Thompson Institute; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99659597802621
- Output Type
- Journal article
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