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International Journal of Endocrinology - 2013 - Naughton - Fatty Acid Modulation of the Endocannabinoid System and the298.30 kB
Published VersionCC BY V4.0, Open Access
Journal article
Fatty Acid Modulation of the Endocannabinoid System and the Effect on Food Intake and Metabolism
International Journal of Endocrinology, Vol.2013, pp.1-11
2013
PMID: 23762050
Abstract
Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system's role in food intake and glucose and lipid metabolism. Importantly, overweight and obese individuals often have higher circulating levels of the arachidonic acid-derived endocannabinoids anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) and an altered pattern of receptor expression. Consequently, this leads to an increase in orexigenic stimuli, changes in fatty acid synthesis, insulin sensitivity, and glucose utilisation, with preferential energy storage in adipose tissue. As endocannabinoids are products of dietary fats, modification of dietary intake may modulate their levels, with eicosapentaenoic and docosahexaenoic acid based endocannabinoids being able to displace arachidonic acid from cell membranes, reducing AEA and 2-AG production. Similarly, oleoyl ethanolamide, a product of oleic acid, induces satiety, decreases circulating fatty acid concentrations, increases the capacity for beta-oxidation, and is capable of inhibiting the action of AEA and 2-AG in adipose tissue. Thus, understanding how dietary fats alter endocannabinoid system activity is a pertinent area of research due to public health messages promoting a shift towards plant derived fats, which are rich sources of AEA and 2-AG precursor fatty acids, possibly encouraging excessive energy intake and weight gain.
Details
- Title
- Fatty Acid Modulation of the Endocannabinoid System and the Effect on Food Intake and Metabolism
- Authors
- Shaan S. Naughton - Victoria UniversityMichael L. Mathai - Florey Institute of Neuroscience and Mental HealthDeanne H. Hryciw - The University of MelbourneAndrew J. McAinch (Corresponding Author) - Victoria University
- Publication details
- International Journal of Endocrinology, Vol.2013, pp.1-11
- Publisher
- John Wiley & Sons Ltd.
- Date published
- 2013
- DOI
- 10.1155/2013/361895
- ISSN
- 1687-8345; 1687-8337
- PMID
- 23762050
- Copyright note
- Copyright © 2013 Shaan S. Naughton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Grant note
- This work has been supported by the Allen Foundation (D. H. Hryciw and A. J. McAinch) and by the Australian Government’s Collaborative Research Networks (CRN) program (A. J. McAinch).
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991187231402621
- Output Type
- Journal article
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