Journal article
Factors Associated With Surgical Site Infections in Adults Following a Replacement of Weight-Bearing Joints: A Systematic Review
International Wound Journal, Vol.23(9), pp.1-22
2026
PMID: 42767272
Abstract
Surgical site infection may occur within 90-days following joint replacement surgery and, in patients undergoing weight-bearing joint replacement, can complicate recovery and adversely affect quality of life. Although numerous studies have identified factors associated with surgical site infections, synthesised and comprehensive evidence specific to weight-bearing arthroplasty remains limited. This systematic review determined the epidemiological associations between intrinsic and extrinsic factors and the development of surgical site infection in adults undergoing hip, knee and/or ankle arthroplasty, using the JBI methodology for systematic reviews of aetiology and risk, and was registered with PROSPERO (CRD42023482491). Studies were retrieved from CINAHL, Medline, Embase, Emcare, the Cochrane Library, and reference lists. English-language observational studies reporting associations between one or more risk factors and surgical site infection following weight-bearing joint replacement were eligible for inclusion. All included studies underwent methodological quality appraisal. Fifty-seven studies met the inclusion criteria. The number of risk factors investigated varied across studies, ranging from a single factor to multiple factors, with multiple factors identified as being significantly associated with an increased risk of surgical site infections at the multivariable levels of analysis. This evidence indicates the need for comprehensive strategies to address these risk factors throughout the patient journey in arthroplasty.
Details
- Title
- Factors Associated With Surgical Site Infections in Adults Following a Replacement of Weight-Bearing Joints: A Systematic Review
- Authors
- Ut T Bui (Corresponding Author) - Queensland University of TechnologyJane O'Brien - Queensland University of TechnologyKathryn Kynoch - Queensland University of TechnologyRosie Glynn - Queensland University of TechnologyChristina Parker - Queensland University of Technology
- Publication details
- International Wound Journal, Vol.23(9), pp.1-22
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2026
- DOI
- 10.1111/iwj.71047
- ISSN
- 1742-481X
- PMID
- 42767272
- Copyright note
- © 2026 The Author(s). International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Data Availability
- The data that support the findings of this study are available from Original data is subject to the authors of included studies. Restrictions apply to the availability of these data, which were used under license for this study. Data are available from the author(s) with the permission of Original data is subject to the authors of included studies.
- Grant note
- This work was supported by the Queensland University's 2023 Women in Research Grant, awarded to the first author.
- Organisation Unit
- Healthy Ageing Research Cluster; School of Health - Nursing
- Language
- English
- Record Identifier
- 991261782302621
- Output Type
- Journal article
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