Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract

David J McMillan; E Medina; C A Guzman; M J Walker

doi:10.1016/S0378-1097(99)00307-9

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Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract

Journal article

Peer reviewed

Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract

David J McMillan, E Medina, C A Guzman and M J Walker

FEMS Immunology and Medical Microbiology, Vol.178(1), pp.7-11

1999

DOI: https://doi.org/10.1016/S0378-1097(99)00307-9

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Abstract

Cardiovascular Medicine and Haematology

Immunology

Medical Microbiology

urease

respiratory challenge

bordetella bronchiseptica

To investigate the role played by urease during the Bordetella bronchiseptica infection process, the ability to colonise and persist in the mouse respiratory tract of a urease-negative B. bronchiseptica BB7865 and a BB7865 derivative constitutively expressing urease was compared with that of the wild-type strain. The results obtained showed that neither constitutive expression nor abolishment of urease activity had any significant effect on the course of B. bronchiseptica infection. Therefore, under our experimental conditions, urease is not essential for B. bronchiseptica to colonise and persist within the murine host.

Details

Title: Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract
Authors: David J McMillan (Author) - University of Wollongong
E Medina (Author) - GBF-National Research Centre for Biotechnology, Germany
C A Guzman (Author) - GBF-National Research Centre for Biotechnology, Germany
M J Walker (Author) - University of Wollongong
Publication details: FEMS Immunology and Medical Microbiology, Vol.178(1), pp.7-11
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 1999
DOI: 10.1016/S0378-1097(99)00307-9
ISSN: 0928-8244
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450380502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Microbiology

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