Journal article
Exploring the validity of mild cognitive impairment (MCI) subtypes: Multiple-domain amnestic MCI is the only identifiable subtype at longitudinal follow-up
Journal of Clinical and Experimental Neuropsychology, Vol.36(3), pp.290-301
2014
Abstract
Background: Epidemiological research exploring risk factors for Alzheimer's dementia resulted in the identification of the mild cognitive impairment (MCI) profile. Subsequently, distinct subtypes of MCI have been proposed; however, the validity of these as diagnostic entities remains uncertain. Design and participants: The aim of the present study was to examine the longitudinal neuropsychological profiles of MCI subtypes. A total of 118 adults aged 60-90 years were classified at screening as amnestic (a-MCI), nonamnestic (na-MCI), and multiple-domain amnestic (a-MCI+) and were assessed at two time points across 20 months on a comprehensive neuropsychological assessment battery. Results: The a-MCI+ group displayed the poorest performance of all groups in terms of episodic memory, working memory, attention, and executive functioning. Conclusions: These findings suggest that the a-MCI+ subtype is the only variant that is recognizable via neuropsychological testing. In contrast, the differentiation between single-domain subtypes and healthy controls is difficult and may not be achievable through current neuropsychological assessment practices.
Details
- Title
- Exploring the validity of mild cognitive impairment (MCI) subtypes: Multiple-domain amnestic MCI is the only identifiable subtype at longitudinal follow-up
- Authors
- S Z Klekociuk (Author) - University of TasmaniaMathew J Summers (Author) - University of Tasmania
- Publication details
- Journal of Clinical and Experimental Neuropsychology, Vol.36(3), pp.290-301
- Publisher
- Routledge
- Date published
- 2014
- DOI
- 10.1080/13803395.2014.890699
- ISSN
- 1380-3395
- Organisation Unit
- School of Health; School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449050402621
- Output Type
- Journal article
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- Clinical Neurology
- Psychology
- Psychology, Clinical
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