Journal article
Exercise training reduces the acute physiological severity of post-menopausal hot flushes
Journal of Physiology, Vol.594(3), pp.657-667
2016
Abstract
A hot-flush is characterised by feelings of intense heat, profuse elevations in cutaneous vasodilation and sweating, and reduced brain blood flow. Exercise training reduces self-reported hot-flush severity, but underpinning physiological data are lacking. We hypothesised that exercise training attenuates the changes in cutaneous vasodilation, sweat rate and cerebral blood flow during a hot flush. In a preference trial, 18 symptomatic post-menopausal women underwent a passive heat stress to induce hot-flushes at baseline and follow-up. Fourteen participants opted for a 16-week moderate intensity supervised exercise intervention, while 7 participants opted for control. Sweat rate, cutaneous vasodilation, blood pressure, heart rate and middle cerebral artery velocity (MCAv) were measured during the hot-flushes. Data were binned into eight equal segments, each representing 12.5% of hot flush duration. Weekly self-reported frequency and severity of hot flushes were also recorded at baseline and follow-up. Following training, mean hot-flush sweat rate decreased by 0.04 mg.cm2.min-1 at the chest (95% CI: 0.02-0.06, P = 0.01) and by 0.03 mg.cm2.min-1 (0.02-0.05, P = 0.03) at the forearm, compared with negligible changes in control. Training also mediated reductions in cutaneous vasodilation by 9% (6-12) at the chest and by 7% (4-9) at forearm (P≤0.05). Training attenuated hot flush MCAv by 3.4 cm/s (0.7-5.1, P = 0.04) compared with negligible changes in control. Exercise training reduced the self-reported severity of hot-flush by 109 arbitrary units (80-121, P<0.001). These data indicate that exercise training leads to parallel reductions in hot-flush severity and within-flush changes in cutaneous vasodilation, sweating and cerebral blood flow.
Details
- Title
- Exercise training reduces the acute physiological severity of post-menopausal hot flushes
- Authors
- Tom G Bailey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringN Timothy Cable (Author) - Liverpool John Moores University, United KingdomNabil Aziz (Author) - Liverpool Women's Hospital, United KingdomGreg Atkinson (Author) - Teeside University, United KingdomDaniel J Cuthbertson (Author) - University Hospital Aintree, United KingdomDavid A Low (Author) - Liverpool John Moores University, United KingdomHelen Jones (Author) - Liverpool John Moores University, United Kingdom
- Publication details
- Journal of Physiology, Vol.594(3), pp.657-667
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2016
- DOI
- 10.1113/JP271456
- ISSN
- 0022-3751
- Copyright note
- Copyright © 2016 Wiley-Blackwell Publishing Ltd. This is the accepted version of the following article: Bailey, Tom G, Cable, N Timothy, Aziz, Nabil, Atkinson, Greg, Cuthbertson, Daniel J, Low, David A, Jones, Helen (2016). Exercise training reduces the acute physiological severity of post-menopausal hot flushes. Journal of Physiology, 594:3, pp.657-667, which has been published in final form at http://dx.doi.org/10.1113/JP271456
- Organisation Unit
- UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99450056502621
- Output Type
- Journal article
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