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Exercise-induced changes to the human gut microbiota and implications for colorectal cancer - a narrative review559.10 kB
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Exercise-induced changes to the human gut microbiota and implications for colorectal cancer: a narrative review
The Journal of Physiology, Vol.600(24), pp.5189-5201
2022
PMID: 36369926
Abstract
Physical activity is associated with reduced risks of colorectal cancer (CRC) incidence, recurrence and mortality. While these findings are consistent, the mechanism/s underlying this association remain unclear. Growing evidence supports the many ways in which differing characteristics of the gut microbiota can be tumourigenic or protective against CRC. CRC is characterised by significant dysbiosis including reduced short chain fatty acid-producing bacteria. Recent findings suggest that exercise can modify the gut microbiota, and these changes are inverse to the changes seen with CRC; however, this exercise-microbiota interaction is currently understudied in CRC. This review summarises parallel areas of research that are rapidly developing: The exercise-gut microbiota research and cancer-gut microbiota research and highlights the salient similarities. Preliminary evidence suggests that these areas are linked, with exercise mediating changes that promote the antitumorigenic characteristics of the gut microbiota. Future mechanistic and population-specific studies are warranted to confirm the physiological mechanism/s by which exercise changes the gut microbiota, and the influence of the exercise-gut interaction on cancer specific outcomes in CRC.
Details
- Title
- Exercise-induced changes to the human gut microbiota and implications for colorectal cancer: a narrative review
- Authors
- Alexander N. Boytar (Author) - The University of QueenslandMarloes Dekker Nitert (Author) - The University of QueenslandMark Morrision (Author) - The University of QueenslandTina L. Skinner (Author) - The University of QueenslandDavid G. Jenkins (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
- Publication details
- The Journal of Physiology, Vol.600(24), pp.5189-5201
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2022
- DOI
- 10.1113/JP283702
- ISSN
- 1469-7793; 0022-3751
- PMID
- 36369926
- Copyright note
- © 2022 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Organisation Unit
- School of Health; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99696658202621
- Output Type
- Journal article
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